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Mouth Diseases clinical trials

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NCT ID: NCT06341959 Recruiting - Oral Disease Clinical Trials

Can a Low-threshold Check-up Motivate Older People to Schedule a Dental Visit?

Start date: April 25, 2024
Phase: N/A
Study type: Interventional

There is little research on the effect of oral screening campaigns for improving oral health in older people. Therefore, the aim of this study is to investigate the effect of a low-threshold contact with an oral health professional, including an oral health examination, on dental attendance of older people (65 years of age or older).

NCT ID: NCT06263439 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Surveillance of HFMD in Pediatric Outpatients

PMB
Start date: June 20, 2023
Phase:
Study type: Observational

The aims of this prospective multicentric study is to determine the types of enteroviruses (EVs) responsible for hand, foot and mouth disease (HFMD) or herpangina in children seen within an ambulatory setting : - to detect an EV-A71 epidemic or another type associated with atypical forms of the disease at an early stage - to describe and compare the epidemiological, demographic, clinical and virological characteristics of these infections between the different types of EV.

NCT ID: NCT06146088 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Lot-to-lot Consistency Study of Three Commercial Batches of Enterovirus 71 Vaccine

Start date: November 25, 2023
Phase: Phase 4
Study type: Interventional

This study is a randomized, blinded study to evaluate the lot-to-lot consistency of immunogenicity, safety, and immune persistence of three consecutive manufacturing lots of EV71 vaccine, in 1500 children aged 6-35 months. The primary immunogenicity endpoint is the anti-EV71 neutralizing antibody geometric mean titer (GMT) 30 days after the final dose. The secondary immunogenicity endpoints are the geometric mean fold increases and seroconversion rates of anti-EV71 neutralizing antibodies 30 days after the final dose. The immune persistence endpoints are the seropositive rates as well as GMT of anti-EV71 neutralizing antibodies 12 and 24 months after the final dose. The safety endpoints are the number of adverse events/reactions within 30 minutes after each dose, the number of solicited adverse events/reactions within 7 days after each dose, the number of unsolicited adverse events/reactions within 30 days after each dose, and the number of serious adverse events (SAE) from the first dose to 6 months post the final dose.

NCT ID: NCT06063057 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Inactivated Bivalent Enterovirus Vaccine (Vero Cell) Phase I/II Clinical Trial

Start date: September 20, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The Phase I clinical trial is divided into two parts. The first part uses an open-label design, while the second part uses a randomized, double-blind, and controlled design. The goal of this clinical trial is to evaluate the tolerability and safety of a bivalent (EV71/CA16, Enterovirus 71/Coxsackievirus A16) inactivated enterovirus vaccine (Vero cell) developed by Sinovac. The vaccine will be administered to healthy adults, children aged 6 to 12 years, and children aged 6 to 71 months. The Phase II clinical trial will also use a randomized, double-blind, and controlled design to evaluate the safety and immunogenicity of the same bivalent inactivated enterovirus vaccine (Vero cell) developed by Sinovac. This trial will involve healthy children aged 6 to 71 months.

NCT ID: NCT05911750 Recruiting - HPV Infection Clinical Trials

Prevalence and Clinical Implications of HPV Infection in Male IBD Patients

PAPIMALE
Start date: February 12, 2023
Phase:
Study type: Observational

The study aims at describing the prevalence of Human Papillomavirus (HPV) infection in anal and oral samples of men with Inflammatory Bowel Disease (IBD) and detecting risk factors for the infection.

NCT ID: NCT05853783 Recruiting - Mouth Diseases Clinical Trials

Evaluation of Oral Potentially Malignant Disorders (OPMDs) With STRATICYTEâ„¢

Start date: January 1, 2023
Phase:
Study type: Observational

The purpose of this study is to validate the ability of the STRATICYTEâ„¢ predictive model to predict the transformation of oral potentially malignant disorders (OPMDs) to oral squamous cell carcinoma (OSCC) in a retrospective cohort of patients who received biopsies.

NCT ID: NCT05707221 Recruiting - Oral Disease Clinical Trials

Effect of Different Cleaning Regimes on Biofilm Formation of Acrylic Based Removable Orthodontic Appliance

Start date: April 17, 2022
Phase: N/A
Study type: Interventional

This study is to evaluate the effects of different cleaning regimes i.e. chemical and mechanical on biofilm formation of an acrylic based removable orthodontic appliance and to find out if surface modification i.e. polished acrylic fitting surface, have an impact on cleaning the biofilm formation.

NCT ID: NCT05656417 Recruiting - Gingivitis Clinical Trials

Individual Variability of Experimental Gingivitis Response

Start date: January 19, 2023
Phase:
Study type: Observational

The study aims to investigate the genetic cause of the variability between individuals seen in the development of the gum disease, gingivitis. This will be carried out through a 3 week programme where all oral hygiene is ceased, allowing 'experimental gingivitis' to develop, followed by a period of recovery when tooth cleaning is restored. Clinical assessments and biological samples will be taken during the course of the study for further analysis.

NCT ID: NCT05390099 Recruiting - Oral Disease Clinical Trials

Anti-Plaque and Anti-Gingivitis Effects of Moringa Plant Extract and Fluoride Toothpastes

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

The present study aims to assess and compare the anti-plaque and anti-gingivitis effects of Moringa plant extract and Fluoride toothpastes among a group of Egyptian Children.

NCT ID: NCT05311410 Recruiting - SARS-CoV2 Infection Clinical Trials

Viral Kinetics of SARS-CoV-2 in Patients With COVID-19 in the Intensive Care Unit Undergoing Dental Procedures

VKSPCICUDP
Start date: September 20, 2021
Phase: N/A
Study type: Interventional

The prevalence and clinical relevance of viremia in patients with COVID-19 have not been well investigated. Seeking to understand the need for dentistry to perform bloody procedures in critically ill patients with COVID-19 admitted to the ICU, the quantification of the magnitude of viral replication may play a fundamental role in this scenario. For this, it is necessary to study the viremia kinetics of SARS-CoV-2, seeking to assess whether there is any characteristic pattern that may be associated with a worse clinical outcome of the patient with COVID-19 after undergoing bloody dental procedures, therefore, the objective of this research will be to investigate the occurrence of viral kinetics produced by dental procedures in patients with SARS-CoV-2 in Intensive Care Units, where, in addition to analyzing the oral health condition, the viral kinetics of SARS-CoV-2 will also be investigated by means of reverse transcription polymerase chain reaction (RT-PCR) examination of blood samples from patients with COVID-19 undergoing bloody dental treatment. This research is expected to identify risks and consequences regarding the possibility of performing bloody dental treatment in patients with COVID-19 in serious condition, in addition to verifying the association of the impact of oral infection foci on this profile of patients.