Developing and Optimizing Transcranial Magnetic Stimulation for Motor Rehabilitation

Motor Skills Clinical Trial

Official title:

Developing and Optimizing Transcranial Magnetic Stimulation for Motor Rehabilitation

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05861284
• Other study ID #: IRB_2303032088
• Status: Not yet recruiting
• Phase: N/A
• Start date: May 1, 2024
• Est. completion date: August 1, 2026

Study information

• Verified date: March 2024
• Source: New Jersey Institute of Technology
• Contact: Elisa Kallioniemi, Ph.D.
• Phone: (973) 596-5269
• Email: elisa.kallioniemi[@]njit.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning.

Description:

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that induces long-term changes in connections between neuronal networks. This and the ability to activate the whole motor system allows the use of TMS to facilitate motor recovery. The motor system has different excitatory states associated with ongoing mu oscillation. Here, the investigators will monitor brain mu oscillations in real-time non-invasively using electroencephalography and modulate the function of the motor system. The investigators will test the impact of three different TMS protocols on motor system neurophysiology and skill learning. These data will provide novel understanding needed to improve TMS approaches for individuals requiring motor rehabilitation.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 45
• Est. completion date: August 1, 2026
• Est. primary completion date: August 1, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• 18-40 years old
• Able to read, understand, and sign the informed consent in English
• Right-handed

Exclusion Criteria:

• A sensory or physical impairment
• History of epilepsy or seizures in the family
• Non-removable metal or electronics (e.g., a cochlear implant, cardiac pacemaker, or implanted electronic devices) in your head or body
• A head injury with loss of consciousness
• Diagnosis of psychiatric or neurological disorder
• Skin defects or active infections on the scalp or hands
• Pregnancy or breastfeeding

Related Conditions & MeSH terms

• Motor Cortex
• Motor Skills

Intervention

Device:
• Transcranial Magnetic Stimulation (TMS)
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Elisa Kallioniemi

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effect of TMS on motor evoked potentials	Amplitude of the motor evoked potentials in millivolts.	Up to 1 second after TMS
Primary	Skill learning accuracy	Skill learning accuracy as the total number of correct responses.	Up to 12 minutes
Primary	Skill learning speed	Skill learning speed in seconds.	Up to 12 minutes