Clinical Trials Logo
  1. Home
  2. Motor Activity
  3. NCT03481309

Modulation of Motor Cortex Excitability by TMS and tDCS (MAGS1)

Motor Activity Clinical Trial

Official title:
Modulation of Motor Cortex Excitability by Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation

Clinical Trial Summary

Investigating modulation of motor cortex excitability by transcranial magnetic stimulation and transcranial direct current stimulation.

Clinical Trial Description

Purpose of this pilot study is to modulate the motor cortex excitability by transcranial magnetic stimulation and transcranial direct current stimulation. Electromyography will be recorded on right abductor digiti minimi muscle to find the motor threshold and measure motor evoked potentials for each healthy participant. In addition, electroencephalography (EEG) data will be collected on the scalp with a high-density EEG net. Eighteen healthy participants will be in this study. Each participant will be seated in a reclining chair and applied non-invasive magnetic and electrical stimulations on the scalp. At baseline, the participant's resting motor threshold (RMT) will be estimated by adjusting the intensity of TMS applied on the left motor cortex to achieve motor-evoked potentials of about 50 uV with 10 TMS pulses at a rate of 0.25 Hz. Then a 3-condition, 3-session, 6-sequence randomized crossover experiment will be used to characterize and compare three versions of tDCS stimulation: anode, cathode, sham. Before and after a 10-min tDCS condition is applied, TMS pulses at 120% of RMT intensity will be applied for 10 minutes and TMS-evoked potential and motor-evoked potential amplitudes will be measured. Each session has at least 1-day gap to remove outlasting effects. We will also be collecting structural magnetic resonance imaging (sMRI) to target primary motor cortex precisely. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03481309
Study type Interventional
Source University of North Carolina, Chapel Hill
Contact
Status Completed
Phase N/A
Start date August 24, 2018
Completion date February 1, 2019
View Details
See also
  Status Clinical Trial Phase
Completed NCT06315036 - Effects of Developmental Gymnastics on Preschoolers' Motor Skills N/A
Completed NCT02915913 - Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults N/A
Completed NCT03162484 - Physical Activity and Chronic Acquired Brain Injury N/A
Terminated NCT02936726 - Examining Exercise, Health Coaching and Meditation for University Employees N/A
Completed NCT02329262 - A Skills-based RCT for Physical Activity Using Peer Mentors N/A
Completed NCT02158130 - Effects of Aerobic Exercise Detraining N/A
Completed NCT01188044 - Validating Accelerometers to Study Physical Activity of Toddlers N/A
Terminated NCT01404039 - Investigating Motor Cortex Processing for Pain Modulation Phase 1
Completed NCT01697124 - The Children in Action Feasibility Study N/A
Not yet recruiting NCT04035863 - Effects of Photobiomodulation on Superficial Sensitivity and Muscle Activity of Individuals With Myelomeningocele N/A
Completed NCT03695523 - PLAY (PhysicaL ActivitY) Policy Study N/A
Active, not recruiting NCT05012241 - The Reliability of the Nine Hole Peg Test in Patients With Multiple Sclerosis
Recruiting NCT03826030 - Transcranial Direct Current Stimulation for Post-stroke Motor Recovery Phase 2
Completed NCT05033197 - Physical Activity, Cognition, Motor Skills, and Well-beings N/A
Completed NCT03146169 - Training Program for Community Health Campaign: Fitter Families Project N/A
Completed NCT03166020 - Evaluation of a Video-ludic Re-education of the Paretic Upper Limb in Chronic Hemipartic Patients Post Cerebral Vascular Accident N/A
Recruiting NCT02264275 - Influence of Aerobic Exercise Training (AET) on Inflammatory Bowel Disease (IBD) in Children and Adolescents N/A
Completed NCT02432924 - Using Combined Instantaneous and Multidimensional Feedback to Support a Change in Physical Activity Behaviour N/A
Completed NCT01697475 - Text-Messaging to Motivate Walking in Older African Americans N/A
Completed NCT04547569 - Somesthesic Role of the Ventro-lateral Prefrontal Cortex in Speech Motor Learning N/A