Motility Disorder of Intestine Clinical Trial
Official title:
Post-Hoc Analysis of Dynamic Magnetic Resonance Sequences to Establish Descriptive Metrics for Small Bowel Motility in Vivo
This project involves the development, validation and application of a novel test using MRI to assess gastrointestinal motility a vital process that mixes the contents of our digestive tract. This process frequently becomes deranged in conditions like chronic constipation, Parkinson's and Crohn's disease.
Gastrointestinal motility refers to the contractile actions in the gut that serve to mix our
food and propel it through out digestive tract. Although known to be involved in a range of
conditions like chronic constipation, Parkinson's and Crohn's disease, investigator have
never had effective tests with which to study the process. Advances in medical imaging
technologies now make it possible to both see and quantify this process non-invasively using
MRI. In this study the investigator first of all validate that our MRI based analysis is
robust and valid, producing predictable results against range of known stimuli. The
investigator then apply the technique to a cohort of participants with Chronic Intestinal
Pseudo-Obstruction. These participants are known to have hypo-motile small bowels and
demonstration with our MRI technique would serve as further validation. The investigator
also investigate two cohorts of people with and without gastrointestinal diseases to better
understand how the technique may work in the clinical setting.
By the end of this project The investigator will have generated robust initial evidence to
validate our MRI technique and clinical data to inform use further research.
;
Observational Model: Case-Only
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03833999 -
Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea
|
Phase 4 |