Immuno-epidemiological and Socio-behavioral Evaluation of Release of Sterile Male Aedes Albopictus Mosquitoes on Human-vector Contacts

Mosquito Bite Clinical Trial

— EXPOCAP  

Official title:

Immuno-epidemiological and Socio-behavioral Evaluation of Release of Sterile Male Aedes Albopictus Mosquitoes on Human-vector Contacts

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05313126
• Other study ID #: 2020-A03558-31
• Status: Recruiting
• Phase: N/A
• Start date: November 9, 2021
• Est. completion date: June 2023

Study information

• Verified date: March 2022
• Source: Institut de Recherche pour le Developpement
• Contact: Franck Remoué, PhD
• Phone: +33 (0)4 67 41 61 30
• Email: franck.remoue[@]ird.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This trial is based on 2 complementary components, named ExpAlbo Biomarker and CAPAlbo Questionnaire

1. ExpAlbo Biomarker (Exposure to the Aedes albopictus mosquito): This component concerns the epidemiological evaluation of the effectiveness of the release of sterile male mosquitoes on the level of exposure of individuals to the bites of the tiger mosquito through the use of a new immunological biomarker of the human-vector contact, developed over the past 20 years by the IRD-MIVEGEC team. Indeed, when a person is bitten by a mosquito, he or she develops a defence reaction, called an immune reaction, against the mosquito's saliva. The main objective of this study is to measure this immune response, and more specifically the antibody response specifically directed against compounds (peptide = small fragment of a protein) in mosquito saliva, and to determine whether this anti-saliva antibody response, and therefore exposure to mosquito bites, decreases when the mosquito control strategy is applied.

2. CAPAlbo Questionnaire: This component is concerned with assessing the impact of sterile male mosquito releases on perceptions and practices related to exposure to Aedes albopictus based on population-based questionnaire surveys. The main objective of these surveys is to determine whether changes in objective exposure to Aedes albopictus mosquitoes are associated with changes in the perception of the nuisance and in the lifestyle habits of respondents, particularly those related to the prevention of mosquito bites (such as the use of repellents or mosquito nets).

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 500
• Est. completion date: June 2023
• Est. primary completion date: June 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• To inhabit on a regular basis in the intervention/control area

• To speak French

Related Conditions & MeSH terms

• Infertility
• Mosquito Bite

Intervention

Other:
• sterile insect technique (TIS)
Sterile male Aedes albopictus mosquitos are released in the area/neighborhood

Locations

Country	Name	City	State
France	population générale (quartier Duparc (Sainte Marie) et Quartier Bois rouge)	La Réunion

Sponsors (1)

Lead Sponsor	Collaborator
Institut de Recherche pour le Developpement

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Immunological indicators	Biomarker based on the measurement of human IgG antibody levels specific to one peptide of Aedes saliva (i.e. Nterm-24kDa salivary peptide)	6 months
Primary	Immunological indicators	Biomarker based on the measurement of human IgG antibody levels specific to one peptide of Aedes saliva (i.e. Nterm-24kDa salivary peptide)	12 months
Primary	Exposure to Aedes mosquito	self-perceived exposure to mosquito will be assessed by questionnaire	6 months
Primary	Exposure to Aedes mosquito	self-perceived exposure to mosquito will be assessed by questionnaire	12 months
Secondary	Protective behavior	a composite indicator derived from a questionnaire will rate the protective behavior of the participants to avoid mosquito bites	6 months
Secondary	Protective behavior	a composite indicator derived from a questionnaire will rate the protective behavior of the participants to avoid mosquito bites	12 months