Monckeberg Medial Calcific Sclerosis Clinical Trial
Official title:
Morphological, Biomechanical and Functional Properties of the Arterial Wall of Athletes: Impact and Consequences of Mechanical Stress on the Cardiovascular Adaptations of Peripheral Arterial Calcifications
The main objective of this study is to obtain data for the integrated analysis of morphological, functional and biomechanical parameters pertaining to lower limb arteries in various categories of elite athletes (without cardiovascular risk and practicing high- or low-impact aerobic activities which preferentially implicate lower limb activity) as compared to (each other and to) sedentary controls.
Secondary objectives of this study are:
A. Determine the presence and extent of intima-media calcifications in athletes B. Determine
the relationship between these calcifications and the level, length and intensity of sports
activity.
C. Determine the relationship between these properties and calcification of the arterial
wall D. Analyze the relationship between the type of sports activity and properties of the
arterial wall.
E. Examine the relationship between the properties of the arterial wall and peripheral
perfusion pressures.
F. Examine the relationship between the properties of the arterial wall, changes in
afterload, morphology and systolic heart function.
G. Analyze the relationships between the parameters characterizing the arterial wall and
muscle mass of the lower limbs.
H. Analyze the relationship between the presence of intramural calcification and bone
density determined by densitometry.
I. Analyze the relationship between the presence of intramural calcification and dietary
protein intake and calcium.
J. Compare indices of pressure at the ankle and toe, depending on the extent of
calcification.
K. Create a collection of biological samples (serum).
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Observational Model: Cohort, Time Perspective: Cross-Sectional
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT02431234 -
Arterial Calcification in the Diabetes
|