Mitral Valve Area Assessment: Comparison With Transthoracic Echocardiography and Magnetic Resonance Imaging

Mitral Valve Stenosis Clinical Trial

Official title:

Quantification of Rheumatic Mitral Stenosis With Cardiac Magnetic Resonance Imaging and Comparison With Transthoracic Echocardiography

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00654472
• Other study ID #: OY1975
• Status: Recruiting
• Phase: N/A
• First received: April 2, 2008
• Last updated: April 7, 2008
• Start date: April 2008
• Est. completion date: June 2008

Study information

• Verified date: April 2008
• Source: Florence Nightingale Hospital, Istanbul
• Contact: Saide Aytekin, Professor
• Phone: 00902122244950
• Email: saideaytekin[@]gmail.com
• Is FDA regulated: No
• Health authority: Turkey:Ministry of Health; Turkey: Ethics Commitee
• Study type: Observational

Clinical Trial Summary

To compare mitral valve area in rheumatic mitral valve stenosis with cardiac magnetic resonance imaging and conventional transthoracic echocardiography.

Description:

Clinical assessment of severity of mitral stenosis depends on both the presence of symptoms and mitral valve area . Evaluation of mitral valve area with transthoracic echocardiography maintains rapid, accurate analysis of valve disease and serves as a practical gold standard for clinical evaluation. Cardiac magnetic resonance imaging (CMRI) is a recently used method that allows to evaluate cardiac structures and function noninvasively. Direct visualization of valve area with CMRI is also possible and it has been shown that the valve area assessed by CMRI planimetry correlates reliably with the invasive assessment. Velocity-encoded cardiac magnetic resonance imaging can be used to quantify mitral valve area. The objective of this study was to evaluate mitral valve area with CMRI and compare it with echocardiographic methods including 2D planimetry, Doppler continuation equation and Doppler pressure half-time

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: June 2008
• Est. primary completion date: June 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years to 65 Years

Eligibility

Inclusion Criteria:

• rheumatic mitral valve stenosis

Exclusion Criteria:

• Degenerative mitral valve disease

• EF<50%

• atrial fibrillation

• inconclusive planimetric assessment

• moderate or severe mitral regurgitation

• moderate or severe aortic regurgitation

• history of previous mitral valve commissurotomy or balloon valvotomy

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Mitral Valve Stenosis

Locations

Country	Name	City	State
Turkey	Florence Nightinngale Hospital	Istanbul
Turkey	TC.Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Florence Nightingale Hospital, Istanbul

Country where clinical trial is conducted

Turkey, 

References & Publications (2)

Djavidani B, Debl K, Lenhart M, Seitz J, Paetzel C, Schmid FX, Nitz WR, Feuerbach S, Riegger G, Luchner A. Planimetry of mitral valve stenosis by magnetic resonance imaging. J Am Coll Cardiol. 2005 Jun 21;45(12):2048-53. — View Citation

Lin SJ, Brown PA, Watkins MP, Williams TA, Lehr KA, Liu W, Lanza GM, Wickline SA, Caruthers SD. Quantification of stenotic mitral valve area with magnetic resonance imaging and comparison with Doppler ultrasound. J Am Coll Cardiol. 2004 Jul 7;44(1):133-7. — View Citation