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Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse — SCIMITAR  

Mitral Valve Prolapse Clinical Trial

Official title:
Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse: the SCIMITAR Trial

Clinical Trial Summary

This is a multicenter, observational prospective and retrospective study which aims are: 1) to compute a scoring model potentially predictive for the diagnosis of fibrosis by CMR in patients with MVP; 2) to identify specific features that may predispose to ≥ mild VAs or SCD in patients with MVP.

Clinical Trial Description

Patients with mitral valve prolapse and non-significant mitral regurgitation generally have a good prognosis. A minority of patients with MVP suffers from ventricular arrhythmias. Different demographic, clinical, and electrocardiographic characteristics, as well as morphological and structural features of the MV were described as potential risk factors for ventricular arrhythmias, among which fibrosis of the left ventricular inferolateral wall and posterior papillary muscle as detected by cardiac magnetic resonance. As cardiac magnetic resonance has some limitations, it is unknown if and which patients with mitral valve prolapse should undergo cardiac magnetic resonance in routine clinical practice, to search for late gadolinium enhancement as a surrogate for myocardial fibrosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06341166
Study type Observational
Source Centro Cardiologico Monzino
Contact Gianluca Pontone, MD
Phone 0258002574
Email gianluca.pontone@cardiologicomonzino.it
Status Recruiting
Phase
Start date June 19, 2023
Completion date June 19, 2025
View Details
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