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NCT03698734 Clinical Trial

Evening Primrose Oil Efficacy in Second Trimester Abortion

Missed Abortion Clinical Trial

Official title:
Effect of Adding Evening Primrose Oil to Misoprostol in Second Trimester Abortion

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03698734
Other study ID # ASU obstetrics hosp
Secondary ID
Status Recruiting
Phase Phase 3
First received
Last updated
Start date November 1, 2018
Est. completion date November 1, 2019

Study information
Verified date October 2018
Source Ain Shams University
Contact Radwa R Ali, MD
Phone 01283492979
Email radwaebed@yahoo.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

efficacy of evening primrose oil in shortening the duration of induction in 2nd trimesteric missed abortion

Recruitment information / eligibility
Status Recruiting
Enrollment 100
Est. completion date November 1, 2019
Est. primary completion date November 1, 2019
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 35 Years
Eligibility Inclusion Criteria:

- Primiparous women

Exclusion Criteria:

- Previous uterine incision( Cs, myomectomy,)

- Contraindications to medical or surgical uterine evacuations (eg, hemodynamically unstable, coagulopathy)

- Evidence of intra-uterine infection

- Rupture of fetal membranes.

- Intrauterine device in place.

- Allergy to prostaglandins or EPO

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Evening primrose oil(EPO)
primiparous women with missed abortion between(13 to 24 weeks) will receive 1 capsule of EPO( 1000mg) in addition to misopristol
• Placebo - Cap
primiparous women with missed abortion between(13 to 24 weeks) will receive 1 capsule of placebo in addition to misopristol

Locations
Country Name City State
Egypt AinShams university maternity hospital Cairo Abbassya

Sponsors (1)
Lead Sponsor Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary duration of medical induction of abortion time needed for complete expulsion of fetus and placenta up to 1 week
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Recruiting NCT04705324 - Dilation and Curettage Versus Operative Hysteroscopy for Missed Abortion N/A
Completed NCT02686840 - Sublingual Versus Vaginal Misoprostol In Medical Treatment of First Trimestric Missed Miscarriage Phase 3
Terminated NCT02342002 - Mifepristone and Misoprostol Versus Misoprostol Alone for Missed Abortion: A Randomized-controlled Trial Phase 4
Recruiting NCT01775917 - The Role of Uterine Artery Doppler Parameters in the Management of Retained Products of Conception. N/A
Active, not recruiting NCT04593108 - Misoprostol With or Without Letrozole in Treatment of Missed Miscarriage
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