Minimally Conscious State Clinical Trial
Official title:
The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study
The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).
Background: Sensory stimulations were used widely to evaluate the preserved cerebral
functions for these patients with disorders of consciousness. Among these, the most alerting
or common stimuli are probably familiar voice and music.
Objective: The aim of the present study was to evaluated the neural effect of music on the
cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state
(MCS) by using functional magnetic resonance imaging (fMRI).
Methods: Eleven severely brain-damaged patients (6 UWS and 5 MCS) were assessed by functional
magnetic resonance imaging while they were exposed under the condition of their personal
music. To examine the prognostic value of these patients, longitudinal behavioral assessments
were repeatedly conducted by means of the CRS-R after fMRI acquisition.
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