A Computer-based Cognitive Stimulation in Mild Cognitive Impairment With White Matter Hyperintensities

Mild Cognitive Impairment Clinical Trial

Official title: Effects of a Computer-based Cognitive Stimulation on the Verbal Learning and the Progression of White Matter Hyperintensities in Mild Cognitive Impairment: A Protocol for a Randomized Controlled Trial.

Status Not yet recruiting

Clinical Trial Summary

This is a non-pharmacological study evaluating the impact of a computerized cognitive stimulation program on verbal learning and on the progression white matter hyperintensities in elderly with mild cognitive impairment.

Clinical Trial Description

White matter hyperintensities (WMH) can appear in Mild Cognitive Impairment (MCI) and have been associated to executive, attention and processing speed deficits. Some findings indicate that the presence of WMH may contribute to Alzheimer's disease (AD) in addition to ß-amyloid, suggesting a greater vulnerability of MCI. One important challenge is to prevent or slowing down the progression of WMH. Few studies investigated the effects of computerized cognitive interventions in MCI with WMH, which deserve special attention. This study aim to investigate the effects of an intensive computer-based cognitive stimulation (CCS) program on the verbal learning in episodic memory in MCI with WMH and to explore the effects on the progression of WMH at 1-year interval. ;

Related Conditions & MeSH terms

• Cognition Disorders
• Mild Cognitive Impairment

• NCT number: NCT03195816
• Study type: Interventional
• Source: Broca Hospital
• Contact: Anne-Sophie AR RIGAUD, Professor
• Phone: 00 33 1440835 03
• Email: anne-sophie.rigaud@brc.aphp.fr
• Status: Not yet recruiting
• Phase: N/A
• Start date: January 2018
• Completion date: March 2019