Migraine Without Aura Clinical Trial
Official title:
Functional MRI (fMRI) in Patients With Migraine Without Aura Provoked by
In patients known with migraine without aura a migraine headache or migraine like headache
will be induced by infusion of calcitonin gene related peptide (CGRP). The patients will
then be stimulated with noxious heat via a thermode placed at the forehead. At the same time
the Blood-oxygenation-level-dependent (BOLD) response will be measured via functional
magnetic resonance imaging (fMRI), to estimate the central-nervous pain response. The
regions of interest (ROI) will be thalamic region and medulla oblongata.
Then the patients will be given pain relif in form of injection of sumatriptan and the
effect of this will also be registered via measuring the BOLD response at the RIO's
previously defined. A 3-Tesla MRI scanner will be used in this trail.
This study will give us key knowledge of the trigeminal pain pathway and the central
processing i.e sensitization during a migraine attach.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Single Blind, Primary Purpose: Treatment
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