Methamphetamine-dependence Clinical Trial
Official title:
The Mechanisms of Cortico-cortical and Cortico-subcortical Networks in Methamphetamine Addiction by Paired Associative Stimulation
Verified date | September 2021 |
Source | Shanghai Mental Health Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The investigators use paired associative stimulation (PAS) protocols to target cortico-cortical and cortico-subcortical networks to study cognitive deficits in methamphetamine addiction.
Status | Active, not recruiting |
Enrollment | 90 |
Est. completion date | March 31, 2022 |
Est. primary completion date | March 31, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - In accordance with the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) for methamphetamine (MA) use disorders - Junior high school degree or above - Normal vision and hearing - Dextromanual Exclusion Criteria: - Have a disease that affect cognitive function such as history of head injury, cerebrovascular disease, epilepsy, etc - Have cognitive-promoting drugs in the last 6 months - Other substance abuse or dependence in recent five years (except nicotine) - Mental impairment, Intelligence Quotient (IQ) < 70 - Mental disorders - Physical disease |
Country | Name | City | State |
---|---|---|---|
China | Haifeng Jiang | Shanghai | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Shanghai Mental Health Center |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change of working memory | The N-Back is a working memory task where the subject is presented with a sequence of stimuli (letters). The task consists of indicating when the current stimulus matches the one from n steps earlier in the sequence. | 30 minutes | |
Primary | Change of response inhibition | Response inhibition was assessed with the SST (Cambridge Cognition, Cambridge, UK). The subject responded to an arrow (go signal), pointing either right or left, by pressing one of two buttons with the right or left index finger. If an audio tone (stop signal) was present, the subject needed to withhold the response. | 30 minutes | |
Primary | Change of attention bias | During the dot-probe task, participants are situated in front of a computer screen with their chin securely placed on a chin rest. Participants are asked to stare at a fixation cross on the center of the screen. Two stimuli, one of which is neutral and one of which is threatening, appear randomly on either side of the screen. The stimuli are presented for a predetermined length of time (most commonly 500ms), before a dot is presented in the location of one former stimulus. Participants are instructed to indicate the location of this dot as quickly as possible, either via keyboard or response box. | 30 minutes | |
Primary | Change of risk decision | The Balloon Analogue Risk Task (BART) is a computerized measure of risk taking behavior. In the task, the participant is presented with a balloon and offered the chance to earn money by pumping the balloon up by clicking a button. Each click causes the balloon to incrementally inflate and money to be added to a counter up until some threshold, at which point the balloon is over inflated and explodes. | 30 minutes | |
Secondary | Change of eeg oscillatory (Alpha, Beta, Theta and Delta) | EEG was recorded to evaluate the changes in the oscillatory domain before and after the stimulation. | 30 minutes | |
Secondary | Change of eeg functional connectivity (Alpha, Beta, Theta and Delta) | EEG was recorded to evaluate the changes of functional connectivity before and after the stimulation. | 30 minutes | |
Secondary | Change of motor evoked potential | Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG). The peak-to-peak amplitude of the EMG response will be measured. | 30 minutes | |
Secondary | Change of resting motor threshold | Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG). The lowest stimulator output needed to elicit a consistent response will be recorded. | 30 minutes |
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