N-Acetyl Cysteine Plus Naltrexone in Methamphetamine Dependence

Status Completed

Clinical Trial Summary

The goal of the proposed study is to evaluate the efficacy and safety of N-Acetyl Cysteine (NAC) in combination with naltrexone in methamphetamine dependence.

Clinical Trial Description

Forty subjects with DSM-IV methamphetamine dependence will receive 8 weeks of double-blind combination medication (NAC plus naltrexone) or placebo. The hypothesis to be tested is that NAC plus naltrexone will be effective and well tolerated in patients with methamphetamine dependence compared to placebo. The proposed study will provide needed data on the treatment of a public health crisis that currently lacks a clearly effective treatment. ;

Study Design

Related Conditions & MeSH terms

Methamphetamine Dependence

Clinical Trial Details

NCT number	NCT00332605
Study type	Interventional
Source	University of Chicago
Contact
Status	Completed
Phase	Phase 2
Start date	June 2006
Completion date	January 2010

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT01813656` - An Study of Aripiprazole in the Treatment of Methamphetamine Dependence	Phase 4
Completed	`NCT00984360` - Study of Naltrexone for Methamphetamine Addiction	Phase 2
Completed	`NCT01685463` - Transcranial Magnetic Stimulation Used to Both Measure Cortical Excitability and Explore Methamphetamine Cue Craving	N/A
Completed	`NCT00569374` - Safety and Tolerability of Modafinil for Methamphetamine Dependence	Phase 2
Completed	`NCT01967381` - Targeting GABA and Opioid Systems for a Pharmacotherapy for Methamphetamine Abuse	Early Phase 1
Completed	`NCT01354470` - A Randomized, Placebo-Controlled Trial of Modafinil for Methamphetamine Dependence	Phase 2
Active, not recruiting	`NCT01044238` - Methylphenidate to Treat Methamphetamine Dependence	Phase 2
Completed	`NCT01215929` - Studying Amphetamine Withdrawal in Humans	Phase 2
Terminated	`NCT01019707` - Safety Assessment of Atomoxetine With MA IV Administration	Phase 1
Completed	`NCT00227123` - A Randomized Control Trial Comparing Quetiapine to Risperidone in Bipolar Disorder With Stimulant Dependence	N/A
Recruiting	`NCT02568878` - Creatine for Depressed Male and Female Methamphetamine Users	Phase 3
Completed	`NCT01011829` - Varenicline vs Placebo for the Treatment of Methamphetamine Dependence	Phase 2
Completed	`NCT01007539` - Efficacy and Safety of CDP-choline in Patients With Methamphetamine Dependence	Phase 3
Completed	`NCT01062451` - An ACE Inhibitor (Perindopril) or an Angiotensin Receptor Blocker (Candesartan) as a Treatment for Methamphetamine Dependence	Phase 1
Completed	`NCT00687713` - Phase 2, Double-Blind, Placebo-Controlled Trial of Bupropion for Methamphetamine Dependence	Phase 2
Completed	`NCT01063205` - NAC as a Potential Treatment for Methamphetamine Dependence	Phase 1
Completed	`NCT02058966` - Pilot Study of Entacapone for Methamphetamine Abuse	Early Phase 1
Completed	`NCT01860807` - Trial of Ibudilast for Methamphetamine Dependence	Phase 2
Terminated	`NCT01813643` - A Comparison of Risperidone and Aripiprazole for Treatment of Patirnts With Methamphetamine-Associated Psychosis	Phase 4
Completed	`NCT01073319` - Rivastigmine as a Treatment for Methamphetamine Dependence	Phase 1