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Clinical Trial Summary

A first in human study to evaluate the safety, tolerability, and pharmacokinetics (PK) of BBO-8520, a KRAS G12C (ON) inhibitor, single agent and in combination with pembrolizumab in patients with advanced non-small cell lung cancer


Clinical Trial Description

This is an open-label, multi-center Phase 1a/1b study designed to evaluate the safety, tolerability, preliminary antitumor activity, and PK of BBO-8520 as a single agent and in combination with pembrolizumab in patients with KRAS (Kirsten rat sarcoma) G12C mutant non-small cell lung cancer. The study includes dose escalation phase, and expansion phase ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06343402
Study type Interventional
Source TheRas, Inc., d/b/a BridgeBio Oncology Therapeutics
Contact TheRas
Phone 650-391-9740
Email onkoras-101ct.gov@bridgebiooncology.com
Status Recruiting
Phase Phase 1
Start date May 22, 2024
Completion date February 2028

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