Effect of Short-chain Fatty Acids on Aerobic Endurance

Status Recruiting

Clinical Trial Summary

Randomized, double-blind, placebo-controlled crossover study designed to determine the effects of increasing colonic short-chain fatty acid (SCFA) content on aerobic endurance in healthy adults, and to identify underpinning mechanisms. In random order, healthy physically active adults will consume provided diets low in fiber and supplemented with SCFA-enriched high amylose maize starch (a poorly digested resistant starch considered a fermentable fiber) or low amylose maize starch (a rapidly digestible starch) for 1-week separated by a ≥2-week washout. At the end of each intervention period, participants will complete an endurance exercise bout followed by a time trial. Biological samples will be collected to assess muscle and whole body metabolism, gut microbiota, inflammation, and gastrointestinal function.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06054607
Study type	Interventional
Source	United States Army Research Institute of Environmental Medicine
Contact	J. Philip Karl, PhD
Phone	508-206-2318
Email	james.p.karl.civ@health.mil
Status	Recruiting
Phase	N/A
Start date	July 21, 2023
Completion date	September 30, 2025

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