Effect of Pomegranate Seed Powder on Markers of Metabolic Syndrome

Metabolic Syndrome Clinical Trial

Official title:

Therapeutic Effects of Pomegranate Seed Powder on Metabolic Syndrome Markers

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05944029
• Other study ID #: UVAS
• Status: Recruiting
• Phase: N/A
• Start date: February 20, 2023
• Est. completion date: August 24, 2023

Study information

• Verified date: July 2023
• Source: University of Veterinary and Animal Sciences, Lahore - Pakistan
• Contact: Shahbano Zahid, Mphil
• Phone: +923095563643
• Email: shahbanozahid265[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Metabolic syndrome is a public health concern worldwide and in Pakistan as well. Abdominal obesity, hyperglycemia, hypertriglyceridemia, hypertension, and low HDL cholesterol are its hallmarks while pomegranate seed's unique chemical composition has sparked research into the health benefits in same arena as weight control, blood lipid profile changes, and other metabolic disturbances. It's high time to study therapeutic efficiency of Pomegranate seed powder against metabolic syndrome.

Description:

Metabolic syndrome, accumulation of certain metabolic risk factors, such as abdominal obesity, hyperglycemia, hypertriglyceridemia, hypertension, and low HDL cholesterol, has been noted as one of the most important risk factors for the epidemic of type 2 diabetes and cardiovascular disease in the 21st century. It has become a significant public health concern and a global epidemic with a prevalence rate of about 25% among American adults. Multiple researches have demonstrated the effectiveness of pomegranate in the management of diabetes, inflammatory conditions, obesity, and blood lipid levels, and consequently metabolic syndrome. Various pomegranate components have the potential to substitute anti-diabetic medications as well Pomegranate seed's unique chemical composition has sparked research into the health benefits, such as weight control, blood lipid profile changes, and other metabolic disorders.

seed powder can influence the patient's metabolic syndrome-related indicators.

Hypothesis:

Pomegranate seed powder can be effective to treat the individuals with impaired metabolism.

Methodology:

In a clinical trial, patients of metabolic syndrome (n=50) will be given pomegranate seed powder dose for over 8 weeks, twice a day. Biochemical outcomes including blood pressure, FBG, cholesterol, hemoglobin level will be determined before and after the completion of trial in addition to patient's weight. Finally, using one-way ANOVA and T-test, collected data will be analyzed.

Expected outcome: The study will explore the potential of pomegranate seed powder in treating metabolic syndrome's risk factors. Therefore, our findings on the studied parameters of patient will assist future researchers in developing tested, evidence-based recommendations.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: August 24, 2023
• Est. primary completion date: July 20, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 30 Years to 60 Years

Eligibility

Inclusion Criteria:

• BMI > 25kg/m2

• Dyslipidemia

• Altered blood glucose level

• Age 30-55 ( male and female)

Exclusion Criteria:

• Thyroid disorder

• Liver disease

• Kidney disorder

• Cancer etc

Related Conditions & MeSH terms

• Metabolic Syndrome
• Syndrome

Intervention

Dietary Supplement:
• Pomegranate seed powder
10 g powder / day

Locations

Country	Name	City	State
Pakistan	University of Veterinary and Animal sciences Lahore	Lahore	Punjab

Sponsors (1)

Lead Sponsor	Collaborator
Asif Ali

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Lipid Profile	The change in Lipid Profile, after consuming Pomegranate seed powder for 7 weeks will be assessed, to look for improvements.	7 weeks
Primary	Fasting Glucose	The change in Blood Glucose level, after consuming Pomegranate seed powder for 7 weeks will be assessed, to look for improvements.	7 weeks
Primary	Blood Pressure	The change in both systolic and diastolic blood pressure after consuming Pomegranate seed powder for 7 weeks will be assessed, to look for improvements.	7 weeks
Primary	Weight	The change in weight, after consuming Pomegranate seed powder for 7 weeks will be assessed, to look for improvements.	7 weeks