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NCT02732509 Clinical Trial

Chronic Inflammation and Exercise Responsiveness

Metabolic Syndrome Clinical Trial

Official title:
Chronic Inflammation and Exercise Responsiveness

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02732509
Other study ID # 16-000437
Secondary ID
Status Completed
Phase
First received
Last updated
Start date March 2016
Est. completion date December 31, 2021

Study information
Verified date January 2022
Source Mayo Clinic
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to determine how chronic inflammation influences skeletal muscle protein metabolism and metabolic function in humans. The investigators will evaluate acute responsiveness to a single bout of exercise in men and women who are either lean or overweight/obese. The investigators will explore the relationship between circulating inflammatory markers and anabolic, proteomic, and transcriptional responses to acute exercise. The investigators will measure skeletal muscle protein synthesis in the postabsorptive state and in response to a single bout of exercise.

Recruitment information / eligibility
Status Completed
Enrollment 146
Est. completion date December 31, 2021
Est. primary completion date December 31, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 30 Years to 55 Years
Eligibility Inclusion Criteria: - Age 30-55 years - BMI 19-45 kg/m2 Exclusion Criteria: - Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl) - Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment) - Renal insufficiency/failure (serum creatinine > 1.5mg/dl) - Oral warfarin group medications or history of blood clotting disorders. - Pregnancy or breastfeeding - Alcohol consumption greater than 2 glasses/day or other substance abuse - Untreated or uncontrolled thyroid disorders - Debilitating chronic disease (at the discretion of the investigators)

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Mayo Clinic Rochester Minnesota

Sponsors (1)
Lead Sponsor Collaborator
Mayo Clinic

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Maximal oxygen consumption rates in mitochondria isolated from skeletal muscles 1 day
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