Hybrid Training and Middle Age

Metabolic Syndrome Clinical Trial

Official title:

Study of Hybrid Training on Lipid Profile and Non-alcoholic Fatty Liver Disease in Middle-aged Obese Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05231564
• Other study ID #: no grant
• Status: Completed
• Phase: N/A
• Start date: November 1, 2019
• Est. completion date: February 1, 2020

Study information

• Verified date: February 2022
• Source: University of Sistan and Baluchestan
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Modern living and physical inactivity results in many ailments, including obesity, non-alcoholic fatty liver disease (NAFLD), and inflammatory issues. Though there are a lot of studies on physical training, there is little detail on hybrid training or electrical and voluntary contractions of the musculature. This study investigated the efficiency of hybrid training in biochemistry, ultrasound, and proinflammatory outcomes in middle-aged sedentary and obese women with NAFLD.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: February 1, 2020
• Est. primary completion date: December 2, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 45 Years to 65 Years

Eligibility

Inclusion Criteria:

• Sedentary women with one to two exercise sessions or less per month
• BMI equal to or above 30 kg/m-2
• WHR equal or above 0.85 m
• Confirmed NAFLD, with grade 2 and 3
• Systolic blood pressure not less than 130 mm Hg and diastolic blood pressure not less than 85 mm Hg
• Increased AST and ALT
• Mean age 45-65 years

Exclusion Criteria:

• Use of 140 grams or more of ethanol per week
• History of depression in the last 6 months
• History of chronic or acute viral hepatitis
• Drug-related liver disease and chronic liver disease
• History of diabetes
• Uncontrolled hypertension
• Myocardial infarction
• Chronic kidney disease
• Hyperthyroidism or heart failure
• Those who have weight loss programs or medical contraindications for physical training
• Serious arterial hemorrhagic disorders
• Serious neurological diseases
• Advanced atherosclerosis
• Elevated fever

Related Conditions & MeSH terms

• Fatty Liver
• Liver Diseases
• Metabolic Syndrome
• Middle Aged
• Non-alcoholic Fatty Liver Disease
• Women's Health

Intervention

Other:
• hybrid training
The experimental group trained two to three sessions of 45 to 50 minutes a week with a recovery of 24 to 48 hours between each session to burn 500 kcal. The first three weeks held hybrid training with a metabolic program and the other three weeks held a strength training program.

Locations

Country	Name	City	State
Iran, Islamic Republic of	Mohammadreza Rezaeipour (MD, PhD)	Zahedan	Sistan And Baluchestan

Sponsors (2)

Lead Sponsor	Collaborator
University of Sistan and Baluchestan	Niloofar Zareie Mohammad Zadeh

Country where clinical trial is conducted

Iran, Islamic Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Body Weight	in kg	Pre-study
Primary	Body Mass Index	in kg/m-2	Pre-study
Primary	Aspartate transaminases	in u/l	Pre-study
Primary	Alanine transaminases	in u/l	Pre-study
Primary	Fasting blood sugar	in mg/dl	Pre-study
Primary	Proinflammatory cytokine (interleukin -6)	in pg/ml	Pre-study
Primary	Ultrasonic assessment	Grade of liver steatosis	Pre-study
Primary	WHR	Waist-to-hip ratio in cm	Pre-study
Primary	SBP/DBP	Systolic blood pressure/Diastolic blood pressure	Pre-study
Primary	HDL Cholesterol Plasma	in mg/dl	Pre-study
Secondary	Body Weight	in kg	six-week
Secondary	Body Mass Index	in kg/m-2	six-week
Secondary	Aspartate transaminases	in u/l	six-week
Secondary	Alanine transaminases	in u/l	six-week
Secondary	Fasting blood sugar	in mg/dl	six-week
Secondary	Proinflammatory cytokine (interleukin -6)	in pg/ml	six-week
Secondary	Ultrasonic assessment	Grade of liver steatosis	six-week
Secondary	WHR	Waist-to-hip ratio in cm	six-week
Secondary	SBP/DBP	Systolic blood pressure/Diastolic blood pressure	six-week
Secondary	HDL Cholesterol Plasma	in mg/dl	six-week