Breaking Sitting and Metabolic Health in Sedentary Overweight and Obese Adults

Metabolic Health Clinical Trial

Official title:

Acute Effects of Breaking Prolonged Sitting on Postprandial Glycaemic Response, Incretin Hormones Secretion and Eating Behaviour in Overweight and Obese Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05306678
• Other study ID #: 201912HM107-
• Status: Completed
• Phase: N/A
• Start date: December 29, 2020
• Est. completion date: March 1, 2023

Study information

• Verified date: April 2024
• Source: National Taiwan Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary overweight and obese adults.

Description:

Two trials are included in this project - Prolonged sitting and Breaking sitting.

In the Prolonged sitting trial, after consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min. In the Breaking sitting trial, after consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min. Blood samples were collected in a regular pattern throughout the trials. Energy balance (e.g., energy intake and spontaneous physical activity) was assessed using food diary and an accelerometer until midnight in the trial days once participants left laboratory.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: March 1, 2023
• Est. primary completion date: March 1, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 45 Years

Eligibility

Inclusion Criteria:

• Physical inactive males and females

• Aged between 20 and 45 years

• Overweight and obese healthy adults (waist circumference greater than 90 cm for males and 80 cm for females)

• Weight stable for more than 3 months (no change in weight +/- 3%)

• Non-smoker

• Able to walk comfortably on a treadmill

Exclusion Criteria:

• Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia

• Waist circumference < 90 cm for male and < 80 cm for female

• Taking medications that may influence lipid or carbohydrate metabolism or immune system function

• Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)

Related Conditions & MeSH terms

• Energy Balance
• Gut Hormones
• Metabolic Health
• Overweight

Intervention

Behavioral:
• Prolonged sitting
After consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min.
• Breaking sitting
After consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min.

Locations

Country	Name	City	State
Taiwan	National Taiwan Normal University	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan Normal University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Gut hormones responses	Changes in blood gut hormones responses (e.g., GLP-1, PYY and GIP concentrations measured in pmol/L) between trials	320 minutes
Secondary	Visual analogue scale (VAS)	Changes in VAS from 0-100 mm (e.g., appetite and mood, etc.) between trials	320 minutes
Secondary	Energy intake	Changes in energy intake (e.g, using a food diary to record) after leaving the laboratory until midnight	600 minutes after leaving the labalotory
Secondary	Physical activity level	Changes in physical activity level (e.g., using an accelerometer to record) after leaving the laboratory until midnight	600 minutes after leaving the labalotory
Secondary	Lipid profile	Changes in blood lipid profile (e.g., TAG and cholesterol, etc.) between trials	320 minutes
Secondary	Blood pressure	Changes in blood pressure (e.g., diastolic and systolic blood pressure) between trials	320 minutes
Secondary	Computerized cognitive testing	Changes in cognitive function (e.g., accuracy and reaction time) between trials	320 minutes
Secondary	Incremental area under curve (iAUC) for metabolic health	Changes in incremental area under curve (iAUC) for insulin and glucose between trials	320 minutes