Intrapleural Cryotherapy for Malignant Pleural Mesothelioma

Status Terminated

Clinical Trial Summary

Can neoadjuvant intrapleural cryotherapy be safely performed in patients with malignant pleural mesothelioma and will it trigger substantial systemic and local pro-inflammatory changes, resulting in the induction of anti-tumor immunity?

Clinical Trial Description

Patients that have been diagnosed, or are suspected of having malignant pleural mesothelioma, a cancer of the pleura, surgery may be considered as an attempt to treat the cancer. As part of the testing needed before surgery, a pleuroscopy or video camera examination of the pleura is necessary to establish the diagnosis and/or to evaluate the extent of the cancer. This study evaluates the effects of cryotherapy (freezing spray) on the ability of a patient's immune system to attack the cancer, as has been reported in other types of cancers. The purpose of this research is to gather information on the safety and effectiveness of cryotherapy in patients with malignant pleural mesothelioma. If successful, this study could provide support for future studies evaluating this new treatment for mesothelioma. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02464904
Study type	Interventional
Source	Mayo Clinic
Contact
Status	Terminated
Phase	N/A
Start date	July 2015
Completion date	February 26, 2021

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