Mental Disorders Clinical Trial
Official title:
The Sustained Effects of Ketamine
The purpose of the study is to characterize the effects of a single, sub-anesthetic dose of ketamine in rs-fMRI in healthy subjects. Post-ketamine rs-fMRI data will demonstrate a pattern of increased global brain connectivity (GBC) in fronto-temporal cortex.
In this study, healthy participants will be randomized into one of two parallel groups: (a) open-label ketamine and active lamotrigine, or (b) open-label ketamine with a matched-placebo control (i.e., sugar pill). All participants will complete a baseline rs-fMRI approximately 1-week prior to the ketamine infusion and a follow-up rs-fMRI 24-hours post-infusion. The subanesthetic dose of ketamine (0.23mg/kg bolus followed by 0.58mg/kg infusion over approximately 60 minutes) will be administered via intravenous infusion to occur during the MRS scan. Participants will be administered lamotrigine (300 mg oral dose) or the matched-placebo control about 2-hours prior to the start of the infusion. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05321602 -
Study to Evaluate the PK Profiles of LY03010 in Patients With Schizophrenia or Schizoaffective Disorder
|
Phase 1 | |
Completed |
NCT05080777 -
Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems
|
N/A | |
Recruiting |
NCT06012149 -
Braining: Implementation of Physical Exercise for Patients in Specialist Psychiatry
|
N/A | |
Recruiting |
NCT03222375 -
SQUEDâ„¢ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism
|
N/A | |
Active, not recruiting |
NCT02836080 -
Integrated Collaborative Care Teams for Youth With Mental Health and/or Addiction Challenges (YouthCan IMPACT)
|
N/A | |
Active, not recruiting |
NCT02907658 -
Efficacy of Internet Use Disorder Prevention
|
N/A | |
Completed |
NCT02710344 -
Using Telehealth to Improve Psychiatric Symptom Management
|
N/A | |
Enrolling by invitation |
NCT02487888 -
A Study of the Impact of Genetic Testing on Clinical Decision Making and Patient Care
|
N/A | |
Recruiting |
NCT02292056 -
Medication Safety and Contraceptive Counseling for Reproductive Aged Women With Psychiatric Conditions
|
N/A | |
Active, not recruiting |
NCT02761733 -
The Effectiveness of a Decision-Support Tool for Adult Consumers With Mental Health Needs and Their Care Managers
|
N/A | |
Completed |
NCT01947283 -
Effectiveness of DECIDE in Patient-Provider Communication, Therapeutic Alliance & Care Continuation
|
N/A | |
Completed |
NCT01633138 -
Performance-based Reinforcement to Enhance Cognitive Remediation Therapy
|
N/A | |
Completed |
NCT01690013 -
Life Quality and Health in Patients With Klinefelter Syndrome
|
N/A | |
Completed |
NCT01656707 -
Adaptive Treatment for Adolescent Cannabis Use Disorders
|
N/A | |
Completed |
NCT01415323 -
Agitation in the Acute Psychiatric Department
|
||
Completed |
NCT01701765 -
Outcomes and Discharge of Long-stay Psychiatric Patients
|
N/A | |
Completed |
NCT00375167 -
Efficacy of the Recovery Workbook as a Psychoeducational Tool for Facilitating Recovery
|
N/A | |
Terminated |
NCT00757497 -
Transcranial Direct Current Brain Stimulation to Treat Patients With Childhood-Onset Schizophrenia
|
Phase 1 | |
Terminated |
NCT03527550 -
Cognitive Control Training for Urgency in a Naturalistic Clinical Setting
|
N/A | |
Withdrawn |
NCT03518996 -
Non-Invasive Brain Stimulation and Delirium
|
N/A |