Meniscus Lesion Clinical Trial
Official title:
Prospective, Double Blind, Randomized Trial: Meniscal Repair With or Without Augmentation Utilizing Platelet Rich Plasma.
This study will compare meniscal healing with or without platelet rich plasma. The
assessments will include validated, disease specific, patient oriented outcome measures, MRI
arthrogram (MRA). Results of this study will help ascertain whether PRP improves meniscal
healing rates.
Null Hypothesis: There is no difference in meniscal healing with or without the use of PRP.
The integrity of the meniscus is pivotal to the distribution of joint reaction forces and
shock absorption across the knee and meniscal damage can lead to secondary degenerative
joint disease. This has lead to treatments directed towards repairing and preserving the
meniscus to alter the progression of joint degeneration. Although success rates of meniscal
repair are greater when performed in association with anterior cruciate reconstruction,
healing rates remain in the 70-80% range for isolated repairs.
Therefore, techniques such as the use of fibrin clots, trephining and rasping of the
tissues, have been incorporated to improve healing results of meniscal repair. There has
been a surge of enthusiasm for the use of Platelet Rich Plasma (PRP) to improve healing
rates of soft tissue injuries. Therefore, it may be reasonable to surmise that applying
blood products, such as thrombin and platelet rich plasma, to the meniscal repair bed may
induce more complete and possibly faster healing.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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