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Meniscus Lesion clinical trials

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NCT ID: NCT05261360 Recruiting - Knee Injuries Clinical Trials

Clinical Efficacy of Exosome in Degenerative Meniscal Injury

KNEEXO
Start date: March 2022
Phase: Phase 2
Study type: Interventional

Comparison of intra-articular administration of synovial fluid-derived mesenchymal stem cells-derived exosomes with synovial fluid-derived mesenchymal stem cells on the same patient.

NCT ID: NCT05149287 Terminated - Meniscus Tear Clinical Trials

PROPER Trial of Pain and Inflammation After Knee Arthroscopy

PROPER
Start date: December 28, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine if ceftriaxone administered postoperatively via intravenous injection reduces postoperative visual analog scale (VAS) pain scores and narcotic consumption in patients undergoing knee arthroscopy for a cartilage or meniscal injury.

NCT ID: NCT05048420 Completed - Sport Injury Clinical Trials

THE EFFECT OF RAMP LESION REPAIR ON RETURN TO SPORTS IN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

Purpose/reason of the research: The anterior cruciate ligament (ACL) is an important ligament in maintaining knee function. In patients with anterior cruciate ligament (ACL) injury, concomitant intra-articular lesions are usually seen. It has been reported that approximately 43% of all patients with ACL tears have associated lateral or medial meniscal injuries. Injury associated with a tear of the meniscotibial ligament in the posterior horn of the medial meniscus is defined as a RAMP lesion. Because the RAMP lesion is located within the posteromedial "blind spot", it has historically been underdiagnosed. It has been reported that 9-17% of all ACL tears have RAMP lesions. RAMP lesions have been found to increase the force on the ACL. Injury to the meniscotibial ligaments has been shown to increase rotational instability of the knee. Based on the available literature, there is a discrepancy between authors regarding the repair of a RAMP lesion during an acute ACL surgery. In chronic ACL rupture, some authors have suggested that the RAMP lesion has a suitable biological environment for healing. thinks. However, excessive mobility of the meniscocapsular junction has been reported in RAMP lesions during knee flexion and extension. It has been suggested that these lesions are different from other peripheral tears and are not suitable for spontaneous healing. It is suggested that meniscal RAMP lesion repair will be the most effective approach. Rehabilitation after repair of a RAMP lesion depends on whether the repair is performed concurrently with ACL surgery. When performed with an ACL surgery, the process is followed according to the ACL rehabilitation protocol. Even if the functionality of the knee is fully restored in the post-ACL surgery period, not all patients can return to their previous level of sportive performance due to various psychological, social and physiological factors. In the literature, different information can be found as criteria for returning to sports after ACL surgery. The rate of returning to sports was reported as 65-88% in patients with ACL reconstruction, and 19-82% in patients who were followed conservatively. However, there are few studies with short- or long-term follow-up after the identification and treatment of RAMP lesions. Accordingly, our aim in this study is to comprehensively evaluate the return to sports of participants who have undergone isolated anterior cruciate ligament surgery and who have had simultaneous RAMP lesion repair with anterior cruciate ligament surgery. This assessment will provide the opportunity to examine functional capacity, balance, psychological state, activity level and pain with different measurement methods. Material and method of the research: The study will consist of 2 groups, including 12 participants who have undergone isolated ACL surgery and 12 participants who have had simultaneous RAMP lesion repair in Istanbul Medipol Mega Hospitals Complex Orthopedics and Traumatology Unit, with a total of 24 participants.

NCT ID: NCT04960436 Completed - Meniscus Lesion Clinical Trials

Clinical Effect of Allogeneic Meniscus Transplantation

Start date: February 1, 2005
Phase: N/A
Study type: Interventional

In this study, patients who underwent allogeneic meniscus transplantation and meniscus resection were followed up for more than 10years to evaluate the long-term efficacy and explore the cartilage protective role of meniscus transplantation.

NCT ID: NCT04921202 Completed - Metabolic Syndrome Clinical Trials

Metabolic Syndrome and Degenerative Meniscus Lesions Related Knee Function

Start date: June 1, 2017
Phase:
Study type: Observational

Studies have suggested that Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis. However, no studies demonstrate the relationship between obese patients with metabolic syndrome and degenerate meniscus lesions and its knee function.The aim is to detect the correlation between obese patients with metabolic syndrome and degenerate meniscus injuries.

NCT ID: NCT04607538 Recruiting - ACL Injury Clinical Trials

The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations.

FKC
Start date: March 1, 2022
Phase:
Study type: Observational

The investigators intend to establish a national cohort including all persons in the ages from 15-20 years old with patellar instability (PI) or a prior knee injury (ACL-ruptur or meniscus damage) . The cohort will be nicknamed "The Faroese Knee Cohort". The overall aim is to investigate two groups. 1. The patella instability group, in which we intend to investigate the following. - Prevalence of patellar dislocation and trochlear dysplasia in the Faroe Islands. - Risk factors for patellar dislocations- - Heredity of trochlear dysplasia. - If there is a specific gene responsible for the development of trochlear dysplasia. - The development of retropatellar artrhosis, its onset and its impact on quality of life and function, 2. Knee injury group (ACL-ruptur or meniscus injury) - The prevalence of ACL-rupture and/or meniscus injury in this specific group in the Faroe Islands. - The impact on quality of life and function.

NCT ID: NCT04436523 Recruiting - Meniscus Lesion Clinical Trials

Blood Flow Restriction After Meniscus Repair

Start date: October 20, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate post-operative outcomes after meniscus surgery in participants undergoing blood flow restriction training as a rehabilitative adjunct compared to those with standard rehabilitation.

NCT ID: NCT04228367 Recruiting - Meniscus Lesion Clinical Trials

JuggerStitch Post Market Clinical Follow-up Study

Start date: September 25, 2020
Phase: N/A
Study type: Interventional

This study is a post-market follow-up study. The data collected from this study will serve the purpose of confirming the safety and performance of the JuggerStitch Device used for meniscal repair according to the product labelling (Instruction For Use).

NCT ID: NCT04153643 Recruiting - Meniscus Lesion Clinical Trials

Meniscus Surgery Registry

Start date: November 15, 2019
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to create a data registry of arthroscopic partial meniscectomies performed at our institution. This information will then be used to examine trends over time, predictive factors, and outcomes of arthroscopic partial meniscectomy.

NCT ID: NCT04129827 Completed - ACL Injury Clinical Trials

Meniscal Lesions in Return to Sport After Anterior Cruciate Ligament Reconstruction

LCA-40
Start date: July 1, 2018
Phase:
Study type: Observational

Most athletes who undergo Anterior Cruciate Ligament Reconstruction (ACLR) plan to return to some level of sporting (RTS) activity. However, rates of return to pre-injury sport are often less than might be expected and many factors influence whether individuals return to sport after this surgery. This study aims to better understand the role of meniscal lesions in RTS and to assess the advantage of the integrated evaluation with clinical, biomechanical and psychological tests to decide the correct RTS timing in non-professional athletes undergoing ACLR.