View clinical trials related to Memory.
Filter by:The investigators tested whether prospective memory is impaired in individuals with Parkinson's Disease compared to controls using reliable and validated experimental measures. Also, the investigators assessed the impact of Parkinson's medication on prospective memory performance in PD to better estimate prospective memory function in PD patients' everyday (chronically treated) life.
1. To evaluate the effects of a single oral (80 mg) dose of propranolol on the encoding of emotional pictures as assessed by peripheral physiological and electrocortical parameters in a healthy population. 2. To evaluate the effects of a single oral (80 mg) dose of propranolol on the retrieval of emotional pictures as assessed by electrocortical parameters in a healthy population. 3. To evaluate correlations between behavioral data and psychophysiological parameters.
Study Objectives: - 1. To examine the extent to which noise typical of nursing units reduces speech intelligibility in acutely ill hospitalized patients - 2. To examine the extent to which noise typical of nursing units impairs recall in acutely ill hospitalized patients - 3. To quantify severity of reduced performance associated with age, familiarity with the healthcare setting, hearing and health status. Plan: One hundred and twenty inpatients from the four medical/surgical nursing units at the Portland VA Medical Center, 60 with normal hearing and 60 with hearing impairment will be recruited to participate in the study. Following assessment to ascertain eligibility and obtaining informed consent, patients will be tested in a sound booth housed at the National Center for Rehabilitative Auditory Research (NCRAR). Designed so that each patient serves as his or her own control, we can accommodate considerable baseline variability between patients without adversely affecting required sample size. Patients' performance in speech intelligibility and recall tests will be measured using a constant level of speech, in controlled environments of no noise (baseline), white noise, hospital noise and hospital noise with speech, all delivered via headphones in pseudo-random order. Performance will be measured in each type of noise at decibel levels equivalent to those currently experienced on nursing units and at lower levels that prior studies have shown are more conducive to effective communication By selecting measures that are particularly relevant to the safe care of hospitalized patients, and that have been studied extensively in healthy populations in highly controlled conditions, we expect to find compelling and unambiguous evidence that hospitalized patients correctly hear and recall very little of what is said to them during their hospitalizations. The majority of hospitalized patients stay on acute care nursing units during most or all of their hospitalizations, making this an appropriate population to study in the context of their responses to the noises typical in these environments. Perhaps most importantly, this study will heighten awareness of health-care personnel to the levels of impairment suffered by their patients - both in their ability to correctly interpret speech and to recall it - in the typical noisy environments of nursing units.
The purpose of this study is to determine whether THC, the main psychoactive ingredient in cannabis, affects functional brain systems underlying memory and reward.
Purpose of this study is to see if different levels of anesthesia have an effect on hearing spoken words without awareness of having heard them or anxiety after surgery.
The purpose of this study is to determine the efficacy and safety of REMEMBER-fX (HT1001, an extract of Panax quinquefolius) in a human sample using standard clinical neuropsychological instruments and side effects rating scales.
The purpose of this research study is to compare a virtual reality display device with the standard neuropsychological evaluation for detecting mild cognitive impairment (problems with memory, concentration, reaction time, etc.).
The primary purpose of the trial is to show that tolterodine ER has no effect on memory and other cognitive abilities in an elderly population
This study, conducted by the NICHD in collaboration with Lancaster University in Lancaster, England, will evaluate the accuracy of information obtained from children using AN ADAPTED VERSION OF NICHD's interview protocol. The NICHD protocol was developed to help forensic interviewers OBTAIN INFORMATION FROM children who may be victims of or witnesses to a crime ABOUT THEIR EXPERIENCES. This study does not involve forensic interviews, but is DESIGNED TO OBTAIN INFORMATION FROM children ABOUT an event that takes place at their school. The study will examine how children report a brief interaction with an unfamiliar adult, how the memory of the event changes over time, and how the use of different interview techniques can help children give a fuller and more accurate accounts of past experiences. Children 5 and 6 years of age who attend local schools in the Lancaster, England, area may be eligible for this study. Participants will be told that they are going to have their pictures taken and will be escorted by a researcher to a room at the school with another researcher who is posing as a photographer. The "photographer" and the child will put on a costume, such as a pirate's outfit, over their street clothes, helping each other put on pieces of the costume. The photographer will take pictures of the child in the costume. They will each take off the costumes and the child will be told that he or she will receive the photographs at a later time. Another researcher posing as a photographer will come into the room, interrupting the event, and begin to argue with the first photographer about who had booked the equipment. They will resolve the argument and apologize to the child for the interruption. About 6 weeks after the event, the children will be interviewed using the ADAPTED VERSION OF NICHD interview protocol. Half will be interviewed first about the staged event (the photo session), followed by an interview about a fictitious event (e.g., a class visit to the fire station) that could plausibly have happened but did not. The other half of the children will be interviewed first about the fictitious event and then about the staged event. The children will be interviewed according to one of the following three procedures: - The NICHD protocol preceded by a rapport-building phase that includes the rules of the interview and open-ended questions about the child and a recently experienced event - The NICHD protocol preceded by a rapport-building phase that includes the rules of the interview and direct questions about the child and a recently experienced event, or - The NICHD protocol preceded by the rules of the interview and open-ended questions about the child, but no opportunity to practice talking about a recently experienced event. After the interviewer has elicited as much information as is likely to be gained from verbal questions, he or she will present the child with a line drawing of a gender neutral person and ask the child to indicate where the child was touched by the photographer and where the child touched the photographer. Any child who provides a report of the fictitious event will be interviewed in the same way about the fictitious event. After 1 year, the children will be interviewed again in the same manner as the 6-week interview. The interviews will be audio- and videotaped to record the kind of information the children talk about and compare it to what actually happened in the event.