Co-trimoxazole as Maintenance Therapy for Melioidosis

Status Completed

Clinical Trial Summary

This is a randomised, open-labelled, controlled trial to compare the efficacy and effectiveness on relapse-free rate of 12-week versus 20-week oral eradication treatment of melioidosis. The study population includes 800 patients with culture-confirmed melioidosis whom 12 weeks of oral eradication therapy have been completed with or without intravenous intensive antibiotics. Patients will be randomised to either stop the eradication treatment or continue current oral treatment for 8 more weeks. The study aim to optimise the regimen used to treat melioidosis for better compliance and reducing unnecessary use of antibiotics.

Clinical Trial Description

Planed interim analysis will be conducted when the patient enrollment reaches 600 cases for evaluating safety and futility of the study. ;

Study Design

Related Conditions & MeSH terms

Melioidosis

Clinical Trial Details

NCT number	NCT01420341
Study type	Interventional
Source	Khon Kaen University
Contact
Status	Completed
Phase	Phase 4
Start date	August 2011
Completion date	June 21, 2019

View Details

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