Melasma Clinical Trial
Official title:
A Split-face Comparison of Low Fluence 1064-nm Q-switched Nd:YAG Laser Plus Vitamin C vs Low Fluence 1064-nm Q-switched Nd:YAG Laser Plus Intradermal Tranexamic Acid Injection for Melasma:a Single Blinded, Randomised Study
BACKGROUND: Melasma is a chronic, often relapsing skin disorder, with poor long-term results
from all current therapies.Q switched 1064nm Nd:YAG laser and intradermal tranexamic acid
both showed efficacy on the treatment of melasma. However, no combination therapy of both be
reported.
OBJECTIVES: To compare the efficacy of low influence Q switched 1064nm Nd:YAG laser and low
influence Q switched 1064nm Nd:YAG laser combined with intradermal tranexamic acid injection
for melasma.
METHODS: Twenty patients with melasma were included in a randomized controlled observer-blinded study with split-face design. Each side of the face was randomly allocated to either six session at two-week interval of low influence 1064 Nd:YAG laser (6 mm spot size, energy fluence 1.2 - 1.4 J/cm 2 at 10 Hz) or low influence 1064nm Nd:YAG laser combined with intradermal tranexamic acid injection.Complication Improvement of melasma was assessed by Melasma area severity index (MASI),physician's global assessment (PhGA), MELASQOL scale, patient's global assessment (PGA), and patient's satisfaction at baseline,6th week,10th week after first treatment and 3 months, and 6 months after last treatment. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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