MB-CART20.1 Melanoma

Status Terminated

Clinical Trial Summary

This is a phase l multi-centric, single arm, prospective, open, dose-escalation study in patients with unresectable stage III oder IV melanoma. The trial will include 15 adult patients. The trial is a classic 3+3 design with 1 Log dose increments and maximum 3 dose levels of the intravenously administered MB-CART20.1.

Clinical Trial Description

This Phase I trial will be the first trial with CD20 CAR transduced T cells in Europe targeting melanoma. The rationale for the trial is based on the finding that melanoma cancer sustaining cells express CD20 and that targeting CD20+ cells in preclinical model has a strong antitumor effect. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03893019
Study type	Interventional
Source	Miltenyi Biomedicine GmbH
Contact
Status	Terminated
Phase	Early Phase 1
Start date	March 8, 2019
Completion date	January 30, 2023

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See also
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