Melanoma (Skin) Clinical Trial
Official title:
Identification of Genomic Lesions Promoting Nodal Metastasis in Malignant Melanoma
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer
may help doctors identify biomarkers related to cancer.
PURPOSE: This research study is looking at tumor tissue samples from patients with stage I,
stage II, or stage III malignant melanoma.
OBJECTIVES:
- Determine the genetic profile of primary melanomas with and without synchronous
regional nodal involvement by examining for 1) activating mutations B-Raf and N-Ras
associated with melanoma development, and 2) allelic imbalances across the genome.
- Compare the genetic profile of primary melanomas from patients with and without lymph
node involvement.
- Determine the combinations of genetic lesions that correlate with nodal metastasis by
adopting a statistical machine learning approach to build a lesion-based classifier for
nodal metastasis.
OUTLINE: Laser capture microdissection is performed on the archived tissue samples to
isolate melanoma cells. DNA is then purified from the samples and amplified using PCR.
Matrix-assisted laser desorption/ionization (MALDI)-time of flight mass spectrometry
technology is used to detect mutations of B-Raf and N-Ras. Single nucleotide polymorphism
arrays are also performed.
Information about the patient's demographics (e.g., TNM staging, sex, age, and tissue
collection dates) will be gathered by chart review or from the Multidisciplinary Melanoma
Conference at University Hospitals tumor conference report in order to match cases.
;
Time Perspective: Prospective
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