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Clinical Trial Summary

One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized by transient postoperative mutism, dysarthria, behavioral, and affective disorders, as well as motor disorders. PFS is thought to be related to axonal lesions. The long-term consequences on the cognitive and psychosocial sphere of PFS have been widely documented. On the other hand, the literature concerning the consequences of this syndrome on language is much restricted. Beyond the language, the role of cerebellum would be central in cognition, some authors even comparing it to a great "conductor" who would underlie the learning of most motor and cognitive automatisms.


Clinical Trial Description

The physiopathology and the anatomo-functional correlates of motor, cognitive, and language functions after surgery of PF tumors are still rare and little known. The objective of this study is to analyze them via morphometric MRI analysis and functional and structural connectivity in children away from PF surgery, coupled with clinical data analysis. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04174820
Study type Observational
Source University Hospital, Angers
Contact Denise Jolivot, MD
Phone 33-(0)2-41-35-58-08
Email DeJolivot@chu-angers.fr
Status Recruiting
Phase
Start date November 12, 2020
Completion date November 1, 2022

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