Medullary Thyroid Carcinoma Clinical Trial
Official title:
Pharmacokinetic and Imaging Optimization Study of Pretargeted Immuno-PET Using the Anti-CEA x Anti-HSG TF2 Bispecific Antibody and 68Ga-IMP-288 Peptide in Patients With Recurrences of Medullary Thyroid Carcinoma.
The aim of this study is to optimize pretargeting parameters using pharmacokinetic and imaging data for immuno-PET using anti-CEA x anti-HSG TF2 BsMAb and 150 MBq of 68Ga-IMP-288 peptide in MTC patients with abnormal Ct serum level after initial complete surgery and at least one abnormal lesion
Variation of TF2 molar dose, IMP-288 molar dose and pretargeting interval will be performed in 4 to 5 cohorts of 3 patients, receiving 30 to 120 nmol of TF2 and 1.5 to 6 nmol of peptides 1 to 3 days apart. Blood samples will be obtained after TF2 and 68Ga-IMP-288 injections. A last cohort (cohorte number 5 or 6) with optimal conditions will be proposed. Whole-body PET images will be recorded 60 and 120 minutes after 68Ga-IMP-288 injection to assess semi-quantitatively tumor targeting and tumor/background ratio. Moreover, the targeting sensitivity of the TF2-pretargeted 68Ga-IMP-288 will be compared to standard methods of tumor. some patient will have a second immuno-TEP for their follow up in the first examen was the most sensible. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT03636945 -
Evaluation of 18F-FDOPA PET-CT in the Preoperative Initial Assessment of Medullary Thyroid Carcinoma
|
N/A | |
| Withdrawn |
NCT01736878 -
Efficacy and Safety Study of Sorafenib to Treat Advanced Medullary Thyroid Carcinoma
|
Phase 2 | |
| Completed |
NCT06067594 -
Calcitonin in Needle Wash Using Electrochemiluminescence Method For Diagnosis Of Medullary Thyroid Carcinoma.
|
||
| Active, not recruiting |
NCT04970134 -
Spanish Study for Molecular Characterization of Thyroid Carcinoma
|
||
| Completed |
NCT01424878 -
Study of Molecular Pathways in Medullary Thyroid Carcinoma and Correlation of Molecular Data With Clinical Behavior of the MTC in Individuals Patients
|
||
| Completed |
NCT02586350 -
Study of Anlotinib in Patients With Medullary Thyroid Carcinoma(ALTER01031)
|
Phase 2/Phase 3 | |
| Completed |
NCT00514046 -
Vandetanib to Treat Children and Adolescents With Medullary Thyroid Cancer
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04787328 -
A Study of HA121-28 Tablets in Patients With Medullary Thyroid Carcinoma (MTC)
|
Phase 2 | |
| Enrolling by invitation |
NCT01511393 -
An Active Surveillance Program for Cases of Medullary Thyroid Carcinoma (MTC)
|
||
| Terminated |
NCT00923247 -
A Targeted Phase I/II Trial of ZD6474 (Vandetanib; ZACTIMA) Plus the Proteasome Inhibitor, Bortezomib (Velcade ), in Adults With Solid Tumors With a Focus on Hereditary or Sporadic, Locally Advanced or Metastatic Medullary Thyroid Cancer (MTC)
|
Phase 1/Phase 2 | |
| Completed |
NCT00880503 -
Collection of Tissue Samples for Study of Multidrug Resistance
|
||
| Not yet recruiting |
NCT06121271 -
Trial of Lu-177 DOTATATE (Lutathera®) in Unlicensed Indications
|
Phase 2 | |
| Completed |
NCT03246659 -
Radiolabelled CCK-2/Gastrin Receptor Analogue for Personalized Theranostic Strategy in Advanced MTC
|
Phase 1 | |
| Recruiting |
NCT05534594 -
Evaluation of the 18F-PSMA Positron Emission Tomography (PET)/CT in Patients With Medullary Thyroid Cancer
|
N/A | |
| Not yet recruiting |
NCT01373736 -
123I-MIBG Scintigraphy in Patients Being Evaluated for Neuroendocrine Tumors
|
Phase 3 |