Step 1 of A Two-step Trial to Evaluate the Effectiveness & Safety of

Updated 04/30/2024

Status Completed

Clinical Trial Summary

This is a Phase II, dose-escalation clinical trial conducted in mechanically ventilated patients receiving sedation no longer than 24 hours. The efficacy, safety, and pharmacokinetics of remimazolam besylate were evaluated using a randomized, single-blind design.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Mechanically Ventilated Patients

Clinical Trial Details

NCT number	NCT06124404
Study type	Interventional
Source	Wuhan Union Hospital, China
Contact
Status	Completed
Phase	Phase 2
Start date	April 8, 2022
Completion date	February 28, 2023

See also
	Status	Clinical Trial	Phase
	Recruiting	`NCT06054503` - Pilot Clinical Investigation to Evaluate a Prototype of Sensor Measuring Ventilator-derived Parameters	N/A
	Completed	`NCT01997931` - The Impact of Bispectral Index Monitoring on Sedation Administration in Mechanically Ventilated Patients	N/A
	Completed	`NCT04134481` - Effect Of Clustered Nursing Interventions On Physiological Response In Critically Ill Patients
	Completed	`NCT05588180` - The Ratio Of Femoral Vein Diameter To Femoral Artery Diameter With Pulse Pressure Variation As A Diagnostic Tool	N/A
	Recruiting	`NCT06153498` - PK/PD Properties and Safety of Remazolam Besylate for Injection in ICU Patients With Impaired Renal Function	Phase 2
	Recruiting	`NCT01256866` - Sedation of Mechanically Ventilated Critically Ill Patients: Midazolam Versus Dexmedetomidine	Phase 4
	Completed	`NCT01237886` - Weaning And Variability Evaluation	N/A
	Completed	`NCT00470821` - Oral Melatonin in Critically Ill High-risk Patients	Phase 4
	Completed	`NCT00322010` - Early Directed Physical Therapy in the Management of Mechanically Ventilated Patients in a Medical Intensive Care Unit	Phase 2
	Completed	`NCT01090258` - Pilot Evaluation of Closed Loop Ventilation and Oxygen Controller	N/A
	Completed	`NCT00199641` - Evaluation of Two Enteral Nutrition Strategies in Mechanically Ventilated Patients	N/A
	Not yet recruiting	`NCT06182553` - Effect of ERCC and/or PEEP-ZEEP Maneuver on Oxygenation, Ventilation, and Airway Secretions Removal in MV Patients	N/A
	Completed	`NCT03524937` - Prevention of Delirium in Intensive Care by Melatonin	Phase 2/Phase 3
	Completed	`NCT03333395` - Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With AECOPD	Phase 4
	Completed	`NCT05387720` - Concurrent Trigger Sensitivity Adjustment And Diaphragmatic Facilitation On Weaning From Mechanical Ventilation	N/A
	Recruiting	`NCT03800849` - Mechanical Ventilation Practices in Uganda's Intensive Care Units
	Not yet recruiting	`NCT05480371` - Cough Assist Device in Mechanically Ventilated Patients	N/A
	Recruiting	`NCT04983615` - Opioid vs. Benzodiazepine-based Sedation for Mechanically Ventilated Patients in the Internal Medicine Ward	N/A
	Completed	`NCT00935896` - High Tidal Volume Induces Inflammation In Normal Lungs	N/A