Mechanical Ventilation Clinical Trial
Official title:
Open, Prospective, Multicenter Trial to Evaluate the Clinical Significance of Combined Serological (Galactomannan ELISA, Beta D Glucan Assay) and Molecular (Nested Aspergillus PCR Assay, Real-time qPCR Assay, Multifungal DNA Microarray) Diagnostic Assays to Detect and Characterize Fungal Pathogens in Bronchoalveolar Lavage (BAL)and Blood Samples of Intensive Care Unit Patients With Pulmonary Infiltrates
The aim of this project is therefore to explore on the clinical significance of analyzing
surrogate markers combined with conventional diagnostics in the ICU setting. BAL, blood and
biopsy samples will be subjected to a combined analysis of GM, BDG, Aspergillus specific PCR
assays in addition to conventional diagnostics (Microscopy, Culture,Histology) for ICU pts
with pulmonary infiltrates.
As GM and BDG are not species-specific, three established and repeatedly published species
specific PCR-based assays (nested PCR, real time PCR assay, multifungal DNA Array)developed
by our group will be investigated in combination with the serological tests in a multicenter
prospective clinical diagnostic trial.
n/a
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