Mechanical Ventilation Weaning Protocol in the Coronary Care Unit

Status Completed

Clinical Trial Summary

The following objectives were used for comparison: 1) primary objective: reintubation rate during hospitalization; 2) secondary objectives: length of hospitalization at the Coronary Care Unit; time from intubation to start of weaning; time from start of weaning to extubation; time from SBT and extubation; presence of respiratory infection in patients requiring reintubation; mortality of patients requiring reintubation.

Clinical Trial Description

Once the cause leading to the need of MV was resolved, patients from both groups underwent a daily clinical evaluation in the mornings, to determine whether they were ready for mechanical ventilation weaning, according to the following clinical SBT criteria: 1) Cause of MV: resolution of the cause and abnormalities leading to MV; 2) neurological stability: patient awake, without or with minimal infusion of sedatives/narcotics, with effective cough and Glasgow scale ≥ 9; 3) cardiovascular stability: mean blood pressure (MBP) ≥ 60 mm Hg, without vasopressors or with low vasopressor doses, heart rate (HR) ≤ 140 / min, hemoglobin (Hb) ≥ 8,0 - 10,0 g/L, partial arterial oxygen pressure (PaO2) ≥ 60 mm Hg with fraction of inhaled oxygen (FiO2) ≤ 0.4, oxygenation index (PaO2 / FiO2) ≥ 150 - 300 without significant respiratory acidosis; 4) metabolic stability: temperature < 37.8° C (armpit) and lack of hydroelectrolytic disorders. ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00557999
Study type	Interventional
Source	Hospital de Base
Contact
Status	Completed
Phase	N/A
Start date	March 2006
Completion date	December 2006

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05921656` - Construction and Evaluation of Airway Leakage Risk Model of Patients With Endotracheal Tube
Recruiting	`NCT03941002` - Continuous Evaluation of Diaphragm Function	N/A
Withdrawn	`NCT04288076` - The Brain and Lung Interaction (BALI) Study	N/A
Completed	`NCT03031860` - Semi-quantitative Cough Strength Score (SCSS)	N/A
Completed	`NCT02312869` - Local Assessment of Management of Burn Patients	N/A
Completed	`NCT02545621` - A Role for RAGE/TXNIP/Inflammasome Axis in Alveolar Macrophage Activation During ARDS (RIAMA): a Proof-of-concept Clinical Study
Completed	`NCT01885442` - TryCYCLE: A Pilot Study of Early In-bed Leg Cycle Ergometry in Mechanically Ventilated Patients	N/A
Completed	`NCT01204281` - Proportional Assist Ventilation (PAV) in Early Stage of Critically Ill Patients	Phase 4
Terminated	`NCT01059929` - Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)	Phase 4
Completed	`NCT00824239` - Intermittent Sedation Versus Daily Interruption of Sedation in Mechanically Ventilated Patients	Phase 3
Completed	`NCT00529347` - Mechanical Ventilation Controlled by the Electrical Activity of the Patient's Diaphragm - Effects of Changes in Ventilator Parameters on Breathing Pattern	Phase 1
Unknown status	`NCT00260676` - Protective Ventilatory Strategy in Potential Organ Donors	Phase 3
Terminated	`NCT00205517` - Sedation and Psychopharmacology in Critical Care	N/A
Completed	`NCT03281785` - Ultrasound of Diaphragmatic Musculature in Mechanically Ventilated Patients.	N/A
Recruiting	`NCT04110613` - RCT: Early Feeding After PEG Placement	N/A
Completed	`NCT04410783` - The Emergency Department Sedation Pilot Trial	N/A
Recruiting	`NCT04821453` - NAVA vs. CMV Crossover in Severe BPD	N/A
Completed	`NCT03930147` - Ventilation With ASV Mode in Children	N/A
Recruiting	`NCT05029167` - REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study)	N/A
Recruiting	`NCT04849039` - Lung Microbiota and VAP Development (PULMIVAP)