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Ventilation and Esophageal Pressure Changes

Mechanical Ventilation Clinical Trial

Official title:
A Study of Intraoperative Transpulmonary and Intrathoracic Pressure Changes Associated With Ventilator Management of Tidal Volume and Positive End-expiratory Pressure (PEEP)

Clinical Trial Summary

A study to observe the effect of variations in ventilator settings including tidal volume and PEEP on transpulmonary pressure monitored with an esophageal balloon catheter and to correlate intraoperative transpulmonary pressure variations and intraoperative stroke volume variation changes.

Clinical Trial Description

This study seeks to observe the effects of variations in ventilator settings on transpulmonary and intrathoracic pressures. More specifically, to observe the impact of variations in tidal volume from 6 mL/kg to 8 mL/kg and PEEP from 0 cm of water (H2O) to 5 cm H2O on transpulmonary and intrathoracic pressures monitored with an esophageal balloon catheter. The impact of this recommended decrease in tidal volume on the clinical utility of stroke volume variation (SVV) as a guide for fluid administration has not been previously examined. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05859672
Study type Observational
Source University of California, Davis
Contact Neal Fleming, MD, PhD
Phone 916 734-5046
Email nwfleming@ucdavis.edu
Status Recruiting
Phase
Start date June 16, 2022
Completion date January 2025
View Details
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