Other Clinical Trial - PCV-VG in Pediatric Laparoscopic Surgery

Status Not yet recruiting

Clinical Trial Summary

This Study will aim to compare the effects of Pressure Controlled Ventilation - Volume Guarantee (PCV-VG) mode with volume control ventilation (VCV) and pressure control ventilation (PCV) modes on respiratory mechanics (including the dynamic compliance, PIP, mean airway pressure, driving pressure..etc) and oxygenation in pediatric laparoscopic surgery.

Clinical Trial Description

Laparoscopic surgery is superior to open surgery in terms of recovery time, less postoperative pain, less wound complications, shorter hospital stay, and earlier return to work. However, carbon dioxide insufflation causes several intraoperative cardiovascular, renal, and respiratory adverse effects. Regarding respiratory effects, elevated Intra-abdominal pressure and abdominal expansion shifts the diaphragm upwards. Thus, intrathoracic pressure increases, and expansion of the lungs is restricted. This is followed by a significant decrease up to 50% in pulmonary dynamic compliance and an increase in peak and plateau airway pressures. After deflation of pneumoperitoneum both the pulmonary compliance and airway pressures return to the baseline levels. High airway pressures and decreased compliance can be associated with pulmonary barotrauma, which may manifest as immediate pneumothorax. The basal lung regions are compressed during elevated IAP causing atelectasis and uneven ventilation-perfusion relationships, impairing gas exchange. Hence, the choice of ventilation mode is very important, especially in the paediatric population. Volume control ventilation (VCV) and pressure control ventilation (PCV) modes have been used but each has its own drawbacks, with the former risking increase in airway pressure when pulmonary compliance changes which can lead to barotrauma and the latter not guaranteeing the desired tidal volume which leads to hypoventilation that presents with hypercarbia. Pressure Control Ventilation - Volume Guarantee (PCV-VG) is a recent controlled ventilation mode that combines the benefits of both volume control ventilation (VCV) and pressure control ventilation (PCV) by delivering the preset tidal volume with a decelerating flow at the lowest possible peak inspiratory pressure during a preset inspiratory time and at a preset respiratory rate ensuring adequate ventilation . ;

Study Design

Related Conditions & MeSH terms

Anesthesia Complication
Mechanical Ventilation Complication

Clinical Trial Details

NCT number	NCT06245317
Study type	Interventional
Source	Assiut University
Contact	Mahmoud M Khalil, MBBS
Phone	1068434214
Email	mahmoud.muhammed1997@gmail.com
Status	Not yet recruiting
Phase	N/A
Start date	February 2024
Completion date	January 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05030337` - Optimising Ventilation in Preterms With Closed-loop Oxygen Control	N/A
Completed	`NCT05144607` - Impact of Inspiratory Muscle Pressure Curves on the Ability of Professionals to Identify Patient-ventilator Asynchronies	N/A
Recruiting	`NCT03697785` - Weaning Algorithm for Mechanical VEntilation	N/A
Completed	`NCT05084976` - Parental Perception of COVID-19 Vaccine in Technology Dependent Patients
Active, not recruiting	`NCT05886387` - a Bayesian Analysis of Three Randomised Clinical Trials of Intraoperative Ventilation
Completed	`NCT04429399` - Lowering PEEP: Weaning From High PEEP Setting	N/A
Completed	`NCT02249039` - Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study	Phase 1
Recruiting	`NCT02071524` - Evaluation of the Effects of Fluid Therapy on Respiratory Mechanics	N/A
Completed	`NCT01114022` - Prevention Inhalation of Bacterial by Using Endotracheal Tube Balloon Polyvinyl Chloride or Polyurethane	N/A
Completed	`NCT00893763` - Strategies To Prevent Pneumonia 2 (SToPP2)	Phase 2
Terminated	`NCT05056103` - Automated Secretion Removal in ICU Patients	N/A
Active, not recruiting	`NCT04558476` - Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation	Phase 2
Recruiting	`NCT05295186` - PAV Trial During SBT Trial
Active, not recruiting	`NCT05370248` - The Effect of 6 ml/kg vs 10 ml/kg Tidal Volume on Diaphragm Dysfunction in Critically Mechanically Ventilated Patient	N/A
Completed	`NCT04589910` - Measuring Thickness of the Normal Diaphragm in Children Via Ultrasound.	N/A
Completed	`NCT04818164` - Prone Position Improves End-Expiratory Lung Volumes in COVID-19 Acute Respiratory Distress Syndrome
Completed	`NCT04193254` - LPP , MP and DP:Relation With Mortality and SOFA in Mechanically Ventilated Patients in ER, Ward and ICU
Not yet recruiting	`NCT03259854` - Non Invasive Mechanical Ventilation VERSUS Oxygen MASK	N/A
Completed	`NCT06332768` - NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients	N/A
Not yet recruiting	`NCT03245684` - Assisted or Controlled Ventilation in Ards (Ascovent)	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.