Cohort Biomonitoring Study to Evaluate the Biocompatibilty of Resin-based Dental Materials

Materials Testing Clinical Trial

Official title: Cohort Biomonitoring Study to Evaluate the Biocompatibilty of Resin-based Dental Materials

Status Not yet recruiting

Clinical Trial Summary

Adult patients who require multiple dental restorations will be included in this study. Urine and saliva samples will be taken for determination of bisphenol A levels at several time points, and for analysis of the estrogenic activity using ERE-CALUX.

Also buccal cells will be taken. Next, DNA extraction will be done with a commercial kit. We will determine global alterations in DNA methylation and DNA hydroxymethylation levels using UPLC-MS/MS.

Clinical Trial Description

n/a

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Related Conditions & MeSH terms

• Materials Testing

• NCT number: NCT02874599
• Study type: Interventional
• Source: Universitaire Ziekenhuizen Leuven
• Status: Not yet recruiting
• Phase: N/A
• Start date: October 2016