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NCT ID: NCT02874625 Not yet recruiting - Materials Testing Clinical Trials

RCT to Evaluate Biocompatibility of Resin-based Dental Materials

Start date: January 2017
Phase: N/A
Study type: Interventional

In this randomized clinical trial, the bio-compatibility of 2 materials used for dental restorations will be compared: glass-ionomer vs resin-based composites. Urine and saliva samples will be taken for determination of bisphenol A levels at several time points, and for analysis of the estrogenic activity using ERE-CALUX. Also buccal cells will be taken. Next, DNA extraction will be done with a commercial kit. Global alterations in DNA methylation and DNA hydroxymethylation levels will be determined using UPLC-MS/MS.

NCT ID: NCT02874599 Not yet recruiting - Materials Testing Clinical Trials

Cohort Biomonitoring Study to Evaluate the Biocompatibilty of Resin-based Dental Materials

Start date: October 2016
Phase: N/A
Study type: Interventional

Adult patients who require multiple dental restorations will be included in this study. Urine and saliva samples will be taken for determination of bisphenol A levels at several time points, and for analysis of the estrogenic activity using ERE-CALUX. Also buccal cells will be taken. Next, DNA extraction will be done with a commercial kit. We will determine global alterations in DNA methylation and DNA hydroxymethylation levels using UPLC-MS/MS.