Surgical Treatment of Marfan Syndrome With Subluxation Lens

Marfan Syndrome Clinical Trial

Official title:

Effect of Different Surgical Treatment of Marfan Syndrome With Subluxation Lens

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05578469
• Other study ID #: 2022-0765
• Status: Active, not recruiting
• Start date: January 1, 2016
• Est. completion date: December 30, 2024

Study information

• Verified date: September 2022
• Source: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To analyze the postoperative visual effects, and to compare the safety and efficacy of different surgical treatment with of Marfan Syndrome with subluxation lens.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 50
• Est. completion date: December 30, 2024
• Est. primary completion date: November 1, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 8 Years to 55 Years

Eligibility

Inclusion Criteria:

1. Patients diagnosed with MFS according to the revised Ghent etiology.

2. refractive errors difficult to correct.

3. pupillary block glaucoma caused by severe dislocation of the lens

Exclusion Criteria:

Keratoconus, late glaucoma, uveitis, history of traumatic lens dislocation, and preoperative retinal rupture with or without retinal detachment (RD)

Related Conditions & MeSH terms

• Lens Subluxation
• Marfan Syndrome
• Syndrome

Intervention

Procedure:
• surgical treatment of Marfan Syndrome with subluxation lens
different surgical treatment of Marfan Syndrome with subluxation lens

Locations

Country	Name	City	State
China	Second Affiliated Hospital, Zhejiang University School of Medicine	Hangzhou

Sponsors (1)

Lead Sponsor	Collaborator
Second Affiliated Hospital, School of Medicine, Zhejiang University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Uncorrected distance visual acuity		1 month postoperatively
Primary	Uncorrected distance visual acuity		3 month postoperatively
Primary	Corrected distance visual acuity		1 month postoperatively
Primary	Corrected distance visual acuity		3 month postoperatively
Primary	intraocular pressure		1 month postoperatively
Primary	intraocular pressure		3 month postoperatively
Primary	postoperative complication		Early and late stages
Secondary	Postoperative astigmatism and astigmatism axial of cornea		1 month postoperatively
Secondary	Postoperative astigmatism and astigmatism axial of cornea		3 month postoperatively
Secondary	endothelial cell count		1 month postoperatively
Secondary	endothelial cell count		3 month postoperatively