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Clinical Trial Summary

Participants are invited to take part in this research study because they have relapsed (cancer has come back) or refractory (cancer has not responded to treatment) B-cell Lymphoma and will be undergoing CAR T-cell Therapy. This research is being done to see if a new radiation therapy administration schedule will positively impact the logistics, time, cost, and side effects of radiation therapy. In this research study, participants will receive radiation therapy once weekly for 5 weeks. This is a novel administration schedule and we're looking to see how this schedule impacts side effects participants may experience, the time spent receiving radiation therapy, how much radiation therapy participants can receive, and how effective this new schedule is.


Clinical Trial Description

This is a feasibility/pilot study of 5 Gy adaptive radiation administered every 5 business days (1 week apart) for 5 weeks prior to standard of care CAR T-cell therapy infusion. Approximately 10 participants with Relapsed/Refractory B-cell Lymphoma will take part in this research study. The primary objective is to assess the feasibility of once weekly radiation therapy for 5 weeks. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06004167
Study type Interventional
Source Massachusetts General Hospital
Contact Chirayu Patel, MD
Phone (617) 724-2430
Email cpatel@mgh.harvard.edu
Status Recruiting
Phase N/A
Start date January 14, 2024
Completion date September 1, 2024

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