Study of LUCAR-20S in Patients With R/R NHL

Status Terminated

Clinical Trial Summary

An open label, single arm Phase I study to evaluate the safety, tolerability, and pharmacokinetics of LUCAR-20S CAR-T cells in relapsed or refractory CD20+ diffuse large B-cell, follicular, mantle cell and small lymphocytic lymphoma.

Clinical Trial Description

This study is an open, dose escalation/dose regimen finding study to assess the safety and pharmacokinetics of donor-derived CD20-directed CAR-T cells administered with lymphodepletion, and to obtain the preliminary efficacy results in subjects who have been diagnosed with relapsed or refractory CD20 positive diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma or small lymphocytic lymphoma. The allo-CAR-T cells will be infused in single-dose. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04176913
Study type	Interventional
Source	The First Affiliated Hospital with Nanjing Medical University
Contact
Status	Terminated
Phase	Phase 1
Start date	December 1, 2020
Completion date	December 9, 2021

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See also
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