The Association Between Periodontal Disease and Malnutrition in a Group of Elderly People in Thailand.

Malnutrition Clinical Trial

Official title:

The Association Between Periodontal Disease and Malnutrition in a Group of Elderly People in Thailand.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05129826
• Other study ID #: MU-DT/PY-IRB 2019/051.1408
• Status: Completed
• Phase: N/A
• Start date: November 1, 2019
• Est. completion date: May 1, 2021

Study information

• Verified date: November 2021
• Source: Mahidol University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will be determine the association between periodontitis and malnutrition status in older adult.

Description:

Ageing may accompany with an accumulation of diseases and impairments cause by physiological, socioeconomic and psychological changes. The older adults are more prone to nutritional deficiencies due to combination of factors such as ageing, excessive polypharmacy, general health decline, poor socioeconomic status, cognitive decline, poor appetite, impaired efficacy of swallowing and limit eating ability.

Periodontitis is a multifactorial disease predominantly a bacterial infection involving the dental biofilm or dental plaque. Periodontitis increases in extent and severity across a large proportion of the human population with ageing. The effects of ageing on the immune system include distinct alterations in both innate and adaptive immune-cell function and effector biomolecules, resulting in processes reflecting immunosenescence, immunoactivation and inflammaging. Moreover, genetic contribution alters immunity and inflammation that play a role in the dysregulation of host responses in ageing. The combination of chronic antigenic burden and uncontrolled inflammatory response can enhance immunosenescence and ageing-associated disease. Periodontitis also has an effect on food intake, nutritional status and quality of life in older adults.

However the relationship between chronic periodontitis and malnutrition in older adult is not clear and needs further study. In this study will be determine the association between periodontitis and malnutrition status in older adult.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 78
• Est. completion date: May 1, 2021
• Est. primary completion date: April 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

1. Subjects who has aged = 60 years old.

2. Subjects who not receive periodontal treatment within the previous 6 months.

3. Subjects who are able to read Thai and express verbal communication.

4. Subjects who are functional independent older adults (get = 12 points from Barthel Index for Activities of Daily Living) [50, 51].

5. Subjects who are cognitive functional independent older adults (get > 23 points from Thai Mental State Examination) [52].

Exclusion Criteria:

1. Subjects with completely edentulous area.

2. Subjects who require antibiotic prophylaxis for dental examination

Related Conditions & MeSH terms

• Malnutrition
• Periodontal Diseases

Intervention

Behavioral:
• the association between periodontitis and malnutrition status
be determine the association between periodontitis and malnutrition status in older adult.

Locations

Country	Name	City	State
Thailand	Kanyawat Rattanasuwan	Bangkok

Sponsors (1)

Lead Sponsor	Collaborator
Mahidol University

Country where clinical trial is conducted

Thailand, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Nutritional status	The nutritional status of the participants will be measured by MNA (Mini Nutritional Assessment) questionnaire. The participants with scores = 24 were classified as having a normal nutritional status, 17 to 23.5 were classified as at risk of malnutrition and <17 were classified as malnutrition.	1 hour
Primary	Periodontal status	The probing pocket depth and clinical attachment level were collected by clinical data collection. The participants who had 4 or more teeth with 1 or more sites with PPD = 4 mm and with clinical attachment loss = 3 mm at the same site was diagnosed as periodontitis.	2 hour
Secondary	Variables that associated with malnutrition in older adult.	The variables that may be associated with malnutrition in all participants were collected. Including, the sociodemographic data and health behavioral information were collected by questionnaires. The anthropometric measurements, masticatory ability, periodontal status, number of teeth and functional tooth units were recorded. The complete data was analyzed for the associated with malnutrition.	1 month