Tuberculosis - Learning the Effect of Parasites and Reinforcing Diets — TB-LEOPARD  

Malnutrition Clinical Trial

Official title: Tuberculosis - Learning the Effect of Parasites and Reinforcing Diets (TB-LEOPARD)

Status Enrolling by invitation

Clinical Trial Summary

The objectives of this research are to determine:

• the burden of intestinal parasitic infections among persons living with pulmonary tuberculosis (TB)

• whether intestinal parasitic infections alter TB treatment outcomes, including speed of sputum clearance and treatment outcomes

• the impact of malnutrition on speed of sputum clearance and TB treatment outcomes

• whether nutritional supplementation improves speed of sputum clearance and treatment outcomes

In this study the researchers will investigate how intestinal parasites impact the nutritional status of TB patients before the start of nutritional supplementation and how they alter the trajectory of weight gain in those receiving supplementation by analyzing results from 2 cohorts.

LEOPARD Cohort 1-

• Control-Enroll TB cases, screen for undernutrition, obtain stool for intestinal parasite screening by polymerase chain reaction (PCR), and assess them for treatment outcomes and weight gain

• TB LION (Learning Impact of Nutrition) - Enroll TB cases, provide nutritional supplementation for 6 months (as part of existing TB LION study), screen for undernutrition, obtain stool for intestinal parasite screening by PCR, and assess them for treatment outcomes and weight gain

LEOPARD Cohort 2 -

• Enroll TB cases, screen for undernutrition, obtain stool for internal parasite screening by PCR, and assess them for treatment outcomes and weight gain.

Clinical Trial Description

LEOPARD Cohort 1-

Control:

• Pulmonary TB patients who are newly diagnosed smear-positive (>/=1+ Acid-fast bacillus/AFB) and whose household contacts are enrolled in the TB-LION (Learning Impact of Nutrition) study but are not receiving nutritional supplementation

• 50 participants will be enrolled and followed for up to 12 months

• Stool sample will be collected at the week 1 visit (visit 2)

• Blood samples will be collected the screening visit, week 1, month 2, and month 6

• Sputum samples will be collected at the screening visit, week 1, week 2, and month 6

TB LION:

• Pulmonary TB patients who are newly diagnosed smear-positive (>/=1+ AFB) and whose household contacts are enrolled in the TB-LION study and are receiving nutritional supplementation

• 50 participants will be enrolled and followed for up to 12 months

• Index case and rest of household will receive nutritional supplementation for 6 months

• Stool sample will be collected at the week 1 visit (visit 2)

• Blood samples will be collected at the screening visit, week 1, month 2, and month 6

• Sputum samples will be collected at the screening visit, week 1, week 2, and month 6

LEOPARD Cohort 2-

• Pulmonary TB patients who are newly diagnosed smear-positive (>/=1+ AFB) and whose household contacts are not enrolled in the TB-LION study

• 300 participants will be enrolled and followed for up to 6 months

• Stool sample will be collected at the week 1 visit (visit 2)

• Blood samples will be collected at the screening visit and week 1

• Sputum samples will be collected at the screening visit, week 1, and week 2 ;

Related Conditions & MeSH terms

• Helminthiasis
• Malnutrition
• Tuberculosis
• Tuberculosis, Pulmonary

• NCT number: NCT05048485
• Study type: Observational
• Source: Boston Medical Center
• Status: Enrolling by invitation
• Start date: April 9, 2022
• Completion date: December 2025