Malignant Tumors Clinical Trial
Official title:
Phase 1 Study of Temozolomide Associated With Topotecan in Refractory or Relapsed Malignant Tumors in Children and Adolescents
Long term survival can now be achieved in 75% of cases of pediatric cancers. However, some types of tumors (ie CNS tumors) or advanced stages (metastatic sarcomas/neuroblastomas) cannot be cured by any treatment. Thus, evaluation of new drugs or combinations are strongly needed. The recommended doses have been defined in children for TMZ (200 mg/m2/d x 5 d) and TPT (1.5 mg/m2/d x 5 d). Some preclinical and clinical studies have shown activity of both drugs in some pediatric cancers. Nevertheless, the association of the two drugs has never been evaluated. The study aims to determine Maximum Tolerated Dose and dose limiting toxicities of each drug when associated and to assess efficacy of the combination.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02041871 -
Interest of PReOPerative Immunonutrition in Liver Surgery for Cancer
|
N/A | |
| Completed |
NCT03110783 -
Bioseal Dural Sealing Study BIOS-14-001
|
Phase 3 | |
| Recruiting |
NCT05516914 -
A Phase Ib/II Clinical Trial of LBL-007 Combined With Tislelizumab in the Treatment of Malignant Tumors
|
Phase 1/Phase 2 | |
| Completed |
NCT02534506 -
Study of Urelumab in Subjects With Advanced and/or Metastatic Malignant Tumors
|
Phase 1 | |
| Recruiting |
NCT05714748 -
Application of mRNA Immunotherapy Technology in Epstein-Barr Virus-related Refractory Malignant Tumors
|
Phase 1 | |
| Recruiting |
NCT05987098 -
BBPA PET/CT in Patients With Malignant Tumors
|
N/A | |
| Not yet recruiting |
NCT01092247 -
The Effect of Ketogenic Diet on Malignant Tumors- Recurrence and Progress
|
N/A | |
| Recruiting |
NCT03160599 -
Restricted Calorie Ketogenic Diet as a Treatment in Malignant Tumors
|
N/A | |
| Recruiting |
NCT04702841 -
CAR - γ δ T Cells in the Treatment of Relapsed and Refractory CD7 Positive T Cell-derived Malignant Tumors
|
Early Phase 1 | |
| Completed |
NCT00165100 -
Dynamic Area Telethermometry (DAT) as an Imaging Modality in Patients With Cancer
|
N/A | |
| Suspended |
NCT05615974 -
A Phase I/II Study of LM-101 Injection in Patients With Advanced Malignant Tumors
|
Phase 1/Phase 2 | |
| Completed |
NCT03542773 -
Targeted Imaging of Glutamate Carboxypeptidase II With DCFPyL-PET
|
Phase 1 | |
| Completed |
NCT05293990 -
Usefulness of Gadovist-enhanced FLAIR Imaging
|
N/A | |
| Completed |
NCT01509612 -
Additive Homeopathy in Cancer Patients
|
Phase 3 | |
| Completed |
NCT01678690 -
An Exploratory Study of Gemcitabine Hydrochloride Oral Formulation (D07001-F4) in Subjects With Malignant Tumors
|
Phase 0 | |
| Suspended |
NCT06270394 -
FAP PET/CT or PET/MR Production in the Diagnosis, Staging, and Efficacy Assessment of Malignant Tumors Application
|
N/A |