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Clinical Trial Summary

Checkpoint inhibitor-related pneumonitis (CIP)is a common fatal immune-related adverse event of PD-1/PD-L1 inhibitors. Some CIP patients have poor effect on hormone therapy, and the remission time of CIP varies greatly. Antifibrotic drugs may be effective in patients with CIP.


Clinical Trial Description

Pirfenidone can inhibit the occurrence and development of pulmonary fibrosis, reduce pulmonary exudation by inhibiting VEGF and promote pulmonary recovery. In our study, subjects with checkpoint inhibitor-related pneumonitis receive pirfenidone plus methylprednisolone or methylprednisolone. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05280873
Study type Interventional
Source Guangzhou Institute of Respiratory Disease
Contact Chengzhi Zhou, MD
Phone 13560351186
Email doctorzcz@163.com
Status Recruiting
Phase Phase 1
Start date October 10, 2021
Completion date October 20, 2024

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