| Eligibility |
Inclusion Criteria:
1. Sign an informed consent form before the trial and have a full understanding of the
trial's content, procedures, and potential adverse reactions.
2. Be able to complete the study according to the trial protocol.
3. Healthy male and female subjects aged 18 to 45 (inclusive) on the day of signing the
informed consent form.
4. Female subjects of childbearing potential must use effective contraception for 1 month
from the date of signing the informed consent form until the last dose. Serum HCG
testing before dosing must be negative. Male subjects with partners of childbearing
potential must agree to use effective contraception measures and avoid sperm donation
during the trial and for 1 month after the last administration of SHR2554.
5. Male subjects must weigh at least 50 kg, and female subjects must weigh at least 45
kg, with a body mass index (BMI) ranging from 19 kg/m2 to 26 kg/m2 (inclusive).
6. Health Condition: No history of heart, liver, kidney, gastrointestinal, neurological,
psychiatric abnormalities, or metabolic disorders.
7. Normal or clinically insignificant findings in vital signs, physical examination,
routine laboratory tests (complete blood count, blood biochemistry, urinalysis,
coagulation function, myocardial enzyme profile, thyroid function), echocardiography,
posteroanterior chest X-ray, and abdominal ultrasound.
8. Fridericia-corrected QT interval (QTcF) of males should = 430 ms, and = 450 ms for
females. Left ventricular ejection fraction (LVEF) should = 50%.
Exclusion Criteria:
1. Positive results on screening tests for hepatitis B surface antigen, hepatitis C
antibodies, syphilis spirochete antibodies, or HIV antibodies.
2. History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity, or
history of hypersensitivity to SHR2554, its excipients, or drugs with a similar
chemical structure or class.
3. Poorly controlled clinical heart symptoms or diseases such as: (1) NYHA Class 2 or
higher heart failure; (2) Unstable angina; (3) Myocardial infarction within the past
year; (4) Any supraventricular or ventricular arrhythmia requiring treatment or
intervention.
4. Occurrence of any of the following conditions within the past 6 months before
screening: Myocardial infarction, severe/unstable angina, NYHA Class II-IV heart
failure, continuous arrhythmias of = Grade 2 (graded based on NCI CTCAE 5.0), heart
failure, second or third-degree atrioventricular block, complete left bundle branch
block, any grade of atrial fibrillation, coronary/peripheral artery bypass grafting or
stent implantation, cerebrovascular accident (including transient ischemic attack),
pulmonary embolism, deep vein thrombosis.
5. Use of any medication within the 4 weeks prior to the initial dose that carries a risk
of prolonged QT/QTc interval or causing torsades de pointes (TdP) arrhythmia; a
history of congenital QT interval prolongation syndrome or a family history of QT
interval prolongation; presence of an implanted pacemaker or automated implantable
cardioverter-defibrillator; uncorrected electrolyte disturbances, or any factors
affecting QT/QTc studies.
6. Pulmonary diseases, including infiltrative lung diseases, pneumonia, and respiratory
distress.
7. Chronic kidney disease, renal insufficiency, or a history of renal anemia.
8. History of difficulty swallowing or any gastrointestinal disorders that affect drug
absorption.
9. Any uncontrolled digestive ulcers, colitis, pancreatitis, etc.
10. Other primary diseases of important organs, such as neurological, cardiovascular,
urological, digestive, respiratory, metabolic, and musculoskeletal system disorders,
which makes the investigator believes it is unsuitable for participation in this
study.
11. Subjects who have undergone any surgery within 3 months prior to screening that could
affect drug absorption, distribution, metabolism, or elimination.
12. Subjects who have undergone any surgery within 6 months prior to screening.
13. Subjects who have taken hepatotoxic drugs (such as acetaminophen, erythromycin,
fluconazole, ketoconazole, rifampin, etc.) within 6 months prior to screening.
14. Subjects who have participated in a clinical trial within 3 months prior to screening.
15. Subjects who have taken known CYP3A or CYP2C19 inducers/inhibitors (see Appendices 2
and 3) within 28 days prior to the first administration of SHR2554.
16. Subjects who have taken any prescription or non-prescription medications within 7 days
prior to the first administration of SHR2554.
17. Subjects who have consumed any vitamin products or herbal supplements within 7 days
prior to the first administration of SHR2554.
18. Subjects who abuse alcohol or excessive intake of alcohol within 6 months prior to
screening, defined as consuming more than 14 units of alcohol per week (1 unit = 285
mL of beer, 25 mL of 40% alcohol, or 100 mL of wine); or subjects with an alcohol
breath test result =20 mg/dL during screening.
19. Subjects who have smoked more than 5 cigarettes per day or habitually use
nicotine-containing products within 3 months prior to screening, and are unable to
quit during the study or have a positive nicotine screening result during screening.
20. Subjects who misuse drugs or have used recreational drugs (such as cannabis) within 3
months prior to screening, or have used hard drugs (such as cocaine, amphetamines,
ecstasy, etc.) within the past year, or have a positive result on drug abuse
(substance abuse) screening during screening.
21. Subjects who have consumed grapefruit or grapefruit-containing products, caffeine,
xanthine, or alcohol-containing foods or beverages within 48 hours prior to the first
administration of SHR2554; engaged in strenuous exercise, or have other factors that
may affect drug absorption, distribution, metabolism, or excretion.
22. Subjects who habitually consume grapefruit juice or excessive amounts of tea, coffee,
and/or caffeinated beverages, and are unable to abstain during the study.
23. Subjects who donated blood within the last 3 months and donated =400 mL of blood or
experienced blood loss =400 mL, donated blood within the last 1 month and donated =200
mL of blood or experienced blood loss =200 mL, or received a blood transfusion.
24. Subjects with a history of syncope or vasovagal episodes, difficulty with blood
collection, or an inability to tolerate venipuncture.
25. Subjects who, in the opinion of the investigator, have other factors that make them
unsuitable for participation in this trial.
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