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Malignant Pleural Effusions clinical trials

View clinical trials related to Malignant Pleural Effusions.

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NCT ID: NCT05543330 Not yet recruiting - NSCLC Stage IV Clinical Trials

A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLC

Start date: September 30, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This is a phase 1/phase 2, multicenter, open-label study to evaluate the safety, tolerability, PK, PD, immunogenicity and preliminary efficacy of M701 in patients with treatment of malignant pleural effusions caused by NSCLC.

NCT ID: NCT03869697 Completed - Clinical trials for Malignant Pleural Effusions

Study With SCB-313 (Recombinant Human TRAIL-Trimer Fusion Protein) for Treatment of Malignant Pleural Effusions

Start date: November 20, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety, tolerability, preliminary efficacy, and PK/PD of SCB-313 (recombinant human TRAIL-Trimer fusion protein) administered once via intrapleural injection (SAD) and once daily over 2 to 3 days (MAD)for the treatment of cancer patients with symptomatic malignant pleural effusions requiring drainage.

NCT ID: NCT02623959 Terminated - Advanced Cancers Clinical Trials

Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis

Start date: April 27, 2016
Phase: Phase 4
Study type: Interventional

The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.

NCT ID: NCT02227732 Completed - Clinical trials for Malignant Pleural Effusions

A Pilot Study Evaluating the Safety and Effectiveness of a New Pleural Catheter for the Medical Management of Symptomatic, Recurrent, Malignant Pleural Effusions

Start date: April 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether a new catheter is safe and effective in treating malignant pleural effusions.

NCT ID: NCT02092155 Enrolling by invitation - Clinical trials for Malignant Pleural Effusions

Biomarker Levels During Indwelling Pleural cAtheter Sample Testing

BLAST
Start date: January 2014
Phase:
Study type: Observational

Some patients that have a tunneled pleural catheter will not have the pleural fluid (water around the lung) return after some time (pleurodesis). The purpose of this study is to understand how the investigators can predict who will achieve pleurodesis and how this occurs by studying the pleural effusion.

NCT ID: NCT00758316 Completed - Clinical trials for Malignant Pleural Effusions

A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions

Start date: September 2008
Phase: Phase 3
Study type: Interventional

Background: Malignant pleural effusions form a significant proportion of respiratory and oncology work-load. The efficacy of thoracoscopic talc poudrage which is the current standard of care is limited by lung entrapment which prevents lung re-expansion. Thoracoscopy patients also have significant hospital length of stay because chest tube drainage must continue until the pleural space is dry to effect successful pleurodesis. Alternative management strategies such as tunnelled pleural catheters (bedside ultrasound-guided) enable outpatient management of pleural effusions but have limited pleurodesis rates and do not offer any chance of getting pleural biopsies. A prospective randomized controlled trial with two arms i.e. thoracoscopic poudrage alone (standard care) versus combined thoracoscopic poudrage and tunnelled pleural catheters. The tunnelled catheters will be inserted at the time of thoracoscopy in the endoscopy centre under ultrasound guidance. The trial is aimed to be completed within 3 years. Primary end-points will be pleurodesis success. The secondary end-points are hospital length-of-stay, complication rates, analgesia requirements, pain scores and quality-of-life scores. Based on power calculations, we aim to recruit 120 patients in each arm.

NCT ID: NCT00430664 Recruiting - Clinical trials for Malignant Pleural Effusions

A Comparative Study of the Safety and Efficacy of Face Talc Slurry and Iodopovidone for Pleurodesis

Start date: January 2006
Phase: N/A
Study type: Interventional

Pleurodesis is a technique used to fuse the two layers of the lining over the lung. This is done to get rid of collections of fluid or air in this space. A common reason would be cancer of the underlying lung or elsewhere causing fluid to collect in the pleural space. In this situation it is a palliative procedure to free the patient from symptoms like breathlessness.

NCT ID: NCT00188474 Completed - Clinical trials for Malignant Pleural Effusions

A Quality of Life Study re Management of Malignant Pleural Effusions

Start date: August 2004
Phase: N/A
Study type: Observational

There is much data in the literature regarding optimal treatment approaches for malignant pleural effusions as assessed by patient outcomes. However, data on quality of life and satisfaction with treatment from the patient's perspective is not available.