CMV IGG Antibodies in Semen as a Predictor for Blood Testis Barrier Damage

Status Recruiting

Clinical Trial Summary

To assess whether the presence of Cytomegalovirus (CMV) Immunoglobulin G (IGG) antibodies in semen is a reliable predictor of male subfertility or infertility.

Clinical Trial Description

Prospective cohort study performed in the artificial reproductive technology (ART) unit. The study will evaluate semen and serum samples from the following groups: 1. Presumably fertile male patients going through ART treatment (for preimplantation genetic testing (PGT) or female indications). 2. Subfertile/infertile male patients with abnormal semen analysis. 3. Male patients suffering from unexplained infertility. All samples will be collected on the day of ovum retrieval procedure, and the semen samples will be evaluated only after completing the fertilization process. The samples will be tested for CMV IGG antibodies and testosterone levels in semen and serum. In addition, anti-sperm antibodies will be measured in the serum. The ratio between CMV IGG antibodies in semen and serum will be calculated, and will be compared with presence of hormone profile, semen analysis parameters and ART parameters. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05302856
Study type	Interventional
Source	Hadassah Medical Organization
Contact	Chana Adler Lazarovits, MD
Phone	00 972 50 8779068
Email	chanaa@hadassah.org.il
Status	Recruiting
Phase	N/A
Start date	March 2, 2022
Completion date	March 2023

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05503862` - Home Semen Testing in Men Beginning Attempts to Conceive	N/A
Recruiting	`NCT03307655` - Relationship Between Nitric Oxide (NO) in Follicular Fluid and Sperm Fertilization Ability	N/A
Withdrawn	`NCT02839447` - A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0
Completed	`NCT00975117` - Spermotrend in the Treatment of Male Infertility	Phase 3
Completed	`NCT00756561` - HOP-2A - Intratesticular Hormone Levels	N/A
Recruiting	`NCT04541459` - Validation of New Devices Against Ambient Electromagnetic Radiation	Early Phase 1
Completed	`NCT02889341` - Valuation of Variable Dose of Docosahexanoic Acid for the Improvement of the Parameters of Male Fertility	N/A
Not yet recruiting	`NCT03167008` - Vitamin D Level vs Semen Parameters
Completed	`NCT02268123` - Correlating In Vitro Fertilization Outcomes After Euploid Blastocyst Transfer With Sperm DNA Fragmentation
Completed	`NCT01232465` - Impact of Sperm DNA Integrity on In Vitro Cycles	N/A
Recruiting	`NCT00119925` - 'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"	N/A
Completed	`NCT03552081` - Tobacco and Sperm Genome: Effects of Smoking Cessation	N/A
Recruiting	`NCT05200663` - Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility	Phase 2
Completed	`NCT02025270` - MSCs For Treatment of Azoospermic Patients	Phase 1/Phase 2
Recruiting	`NCT06147700` - Identifying Molecular Determinants of Infertility in Men (MODIFY)
Recruiting	`NCT06188936` - Home Semen Analysis Tests as a Screening Tool for Fertility Patients	N/A
Recruiting	`NCT04200118` - Epigenetic and Genetic Effects in Cancer Patients: Analysis Pre and After Treatment
Terminated	`NCT02605070` - Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia	Phase 3
Completed	`NCT01407432` - Impact of Folates in the Care of the Male Infertility	Phase 3
Completed	`NCT00596739` - A Study of the Pre- and Post-operative Semen Analyses and Reproductive Hormone Levels of Men Undergoing Weight-reduction Surgery	N/A