Male Infertility Clinical Trial
Many cases of male infertility are poorly understood and regarded as unexplained. Therefore, a etiological treatment for this condition can not be offered in most cases. A beneficial effect on sperm motility was found in trails using antioxidants such as carnitine, zinc and folic acid. However, most studies lacked a sufficient power to detect a significant effect on pregnancy rates. In this study, infertile men with abnormal sperm quality parameters will be randomized to receive either carnitine-based food supplement (Porimore) or folate and Zinc Tablets.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | December 2012 |
Est. primary completion date | February 2010 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - infertility - at least one abnormal sperm quality parameter - female age < 35 - normal ovarian reserve Exclusion Criteria: - known allergy to one of the food additives planned for treatment |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Israel | Shaare-Zedek IVF and infertility unit | Jerusalem |
Lead Sponsor | Collaborator |
---|---|
Shaare Zedek Medical Center |
Israel,
Isidori AM, Pozza C, Gianfrilli D, Isidori A. Medical treatment to improve sperm quality. Reprod Biomed Online. 2006 Jun;12(6):704-14. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pregnancy Rate | proportion of women becoming pregnancy following treatment with intrauterine insemination | 3 Insemination cycles | No |
Secondary | Sperm quality parameters | 3 months | No |
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