Male Infertility Clinical Trial
Official title:
Increased Testicular Cd2+ & Infertility With Varicocele ( a Varicose Vein in the Scrotum)
Varicose veins in the scrotum (varicocele) are responsible for >20% of male infertility in
the US. Varicocele are associated with decreased sperm number and markedly reduced sperm
fertilizing ability. Surgical repair or removal of varicocele restores fertility in only 1/3
of cases. The goal of this study is to identify markers that predict the outcome of
variocele correction. This would offer considerable health cost savings.
Based on preliminary findings, we will obtain testis biopsies and semen specimens from
infertile men with varicocele and prospectively examining the levels of cadmium, a toxic
metal, and expression of genes required for normal sperm function. The semen and biopsies
will be obtained during clinically dictated procedures. Cadmium and gene expression will be
compared with response to varicocele repair (i.e., increased sperm production; pregnancy).
n/a
Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal
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